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. 2022 Sep 21;84(10):1335-1339.
doi: 10.1292/jvms.22-0289. Epub 2022 Aug 17.

Comparison of the alkalizing abilities between 1.35% sodium bicarbonate solutions with and without dextrose in healthy calves

Kaoru Sato  1   2 , Kenji Tsukano  3 , Mayumi Kurata  1 , Tadaharu Ajito  4 , Haruyuki Hirata  2 , Kazuyuki Suzuki  2
Affiliations

Comparison of the alkalizing abilities between 1.35% sodium bicarbonate solutions with and without dextrose in healthy calves

Kaoru Sato et al. J Vet Med Sci. .

Abstract

The present study aimed to clarify the alkalizing ability of 1.35% isotonic sodium bicarbonate solution (ISBS), which did not contain dextrose, compared with that of 1.35% isotonic bicarbonate sodium solution containing 4.03% dextrose (ISBD) in healthy calves. The calves were intravenously administered with 20.7 mL/kg of the solutions for 30 min as the volume required to correct base deficit of 10 mM. ISBS increased the blood pH, HCO3-, and base excess from 7.44 ± 0.02, 29.6 ± 1.9 mM, and 5.3 ± 2.1 mM to 7.49 ± 0.02, 36.9 ± 2.3 mM, and 13.5 ± 2.6 mM respectively (P<0.05). These factors for the ISBD group increased from 7.41 ± 0.02, 29.0 ± 1.1 mM, and 4.5 ± 1.3 mM to 7.43 ± 0.02, 33.5 ± 1.9 mM, and 9.5 ± 1.7 mM (P<0.05), respectively. Furthermore, in the ISBD group, the relative plasma volume and blood glucose level increased while the K+ level decreased, which did not occur in the ISBS group. Therefore, the results revealed that ISBS had better alkalizing ability in calves than ISBD.

Keywords: calf; dextrose; hyperkalemia; isotonic sodium bicarbonate; metabolic acidosis.

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Figures

Fig. 1.
Fig. 1.
Graphs depicting the blood pH, HCO3− and base excess (BE) levels in calves given ISBS and ISBD. The alphabet (a) indicates the data were significantly different at each time point between ISBS and ISBD groups using the Student’s t-test or Welch’s t-test. ISBS: isotonic NaHCO3 solution, ISBD: ISBS with 4.03% dextrose. Daggers (†) and asterisks (*) indicate the data was significantly different from the pre-value (Time=0 hr) at each measurement time point after the administration of ISBS and ISBD using Dunnett’s test.
Fig. 2.
Fig. 2.
Graphs depicting the blood TCO2 and PCO2 levels in calves given ISBS and ISBD. The alphabet (a) indicates the data were significantly different at each time point between ISBS and ISBD groups using the Student’s t-test or Welch’s t-test. ISBS: isotonic NaHCO3 solution, ISBD: ISBS with 4.03% dextrose. Daggers (†) and asterisks (*) indicates the data was significantly different from the pre-value (Time=0 hr) at each measurement time point after the administration of ISBD using Dunnett’s test.
Fig. 3.
Fig. 3.
Graphs depicting the rPV and glucose (GLU) levels in calves given ISBS and ISBD. The alphabet (a) indicates the data were significantly different at each time point between ISBS and ISBD groups using the Student’s t-test or Welch’s t-test. ISBS: isotonic NaHCO3 solution, ISBD: ISBS with 4.03% dextrose. Daggers (†) and asterisks (*) indicate the data was significantly different from the pre-value (Time=0 hr) at each measurement time point after the administration of ISBS and ISBD using Dunnett’s test.
Fig. 4.
Fig. 4.
Graphs depicting the blood Na+, K+ and Cl− levels in calves given ISBS and ISBD. ISBS: isotonic NaHCO3 solution, ISBD: ISBS with 4.03% dextrose. Dagger (†) and asterisks (*) indicate the data was significantly different from the pre-value (Time=0 hr) at each measurement time point after the administration of ISBS and ISBD using Dunnett’s test.
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