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. 2022 Nov;31(6):e13689.
doi: 10.1111/ecc.13689. Epub 2022 Aug 18.

The global, regional, national burden of laryngeal cancer and its attributable risk factors (1990-2019) and predictions to 2035

Changwei Lin  1   2 , Wenwei Cheng  3   4 , Xiajing Liu  5 , Heqing Li  6 , Yexun Song  6
Affiliations

The global, regional, national burden of laryngeal cancer and its attributable risk factors (1990-2019) and predictions to 2035

Changwei Lin et al. Eur J Cancer Care (Engl). 2022 Nov.

Abstract

Objective: We aim to report the incidence, mortality and disability-adjusted life years (DALYs) between 1990 and 2019 and provide predictions to 2035.

Methods: We use estimates from Global Burden of Disease, Injuries and Risk Factors Study 2019 to analyse the incidence, mortality and DALYs.

Results: In 2019, there were more than 209,149 incidence cases, with age-standardised rates (ASRs) of 2.5. Laryngeal cancer accounted for 123,356 death cases, with ASRs of 1.5. Laryngeal cancer was also responsible for 3.26 million (3,034,634 to 3,511,354) DALYs, with ASRs of 38.8 (36.1 to 41.8). In 2019, Central Europe had the highest age-standardised incidence rate. At the national level, the highest incidence rate was observed in Mongolia. Total number and rate were significantly higher among males than females across all age groups. DALYs were attributable to Alcohol use, Smoking, Occupational exposure to sulfuric acid and asbestos. The age-standardised incidence rates in seven GBD regions and 59 countries are projected to increase between 2019 and 2035.

Conclusions: Despite the current and predicted decline in age-standardised incidence globally, the absolute number of estimates continue to increase. Prevention programmes should concentrate on modifiable risk factors, especially among the males across all age groups.

Keywords: epidemiology; global burden of disease; laryngeal cancer; prediction.

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References

REFERENCES

    1. Asad, S. I. (2019). Anti-smoking measures implemented by educational institutions and the prohibition of smoking and protection of non-smokers health ordinance, 2002. The Journal of the Pakistan Medical Association, 69(11), 1700-1704. https://doi.org/10.5455/JPMA.2922
    1. Bonomi, M. R., Blakaj, A., & Blakaj, D. (2018). Organ preservation for advanced larynx cancer: A review of chemotherapy and radiation combination strategies. Oral Oncology, 86, 301-306. https://doi.org/10.1016/j.oraloncology.2018.10.004
    1. Bray, F., Ferlay, J., Soerjomataram, I., Siegel, R. L., Torre, L. A., & Jemal, A. (2018). Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians, 68(6), 394-424. https://doi.org/10.3322/caac.21492
    1. Caston, J. C., Finklea, J. F., & Sandifer, S. H. (1972). Cancer of the larynx and lung in three urban counties in South Carolina. Southern Medical Journal, 65(6), 753-756. https://doi.org/10.1097/00007611-197206000-00025
    1. Chan, C. K., & Gee, J. B. (1988). Asbestos exposure and laryngeal cancer: An analysis of the epidemiologic evidence. Journal of Occupational Medicine, 30(1), 23-27. PMID: Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/3280756

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