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Review
. 2022 Jul 11;23(4):505-513.
doi: 10.5811/westjem.2022.3.55325.

Multisystem Inflammatory Syndrome in Children

Muhammad Waseem  1 , Masood A Shariff  1 , C Anthoney Lim  2 , Jeranil Nunez  2 , Nisha Narayanan  3 , Kavita Patel  4 , Ee Tein Tay  4
Affiliations
Review

Multisystem Inflammatory Syndrome in Children

Muhammad Waseem et al. West J Emerg Med. .

Abstract

Multisystem inflammatory syndrome in children (MIS-C) is an uncommon but emerging syndrome related to SARS-CoV-2 infection. While the presentation of MIS-C is generally delayed after exposure to the virus that causes coronavirus 2019, both MIS-C and Kawasaki disease (KD) share similar clinical features. Multisystem inflammatory syndrome in children poses a diagnostic and therapeutic challenge given the lack of definitive diagnostic tests and a paucity of evidence regarding treatment modalities. We review the clinical presentation, diagnostic evaluations, and management of MIS-C and compare its clinical features to those of KD.

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Conflict of interest statement

Conflicts of Interest: By the WestJEM article submission agreement, all authors are required to disclose all affiliations, funding sources and financial or management relationships that could be perceived as potential sources of bias. No author has professional or financial relationships with any companies that are relevant to this study. There are no conflicts of interest or sources of funding to declare.

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Supplementary concepts