Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2022 Oct;15(5):e003867.
doi: 10.1161/CIRCGEN.122.003867. Epub 2022 Aug 18.

Dissecting the Genomics of Spontaneous Coronary Artery Dissection

Chad S Weldy  1   2 , Ryan Murtha  1   2 , Juyong Brian Kim  1   3
Affiliations
Editorial

Dissecting the Genomics of Spontaneous Coronary Artery Dissection

Chad S Weldy et al. Circ Genom Precis Med. 2022 Oct.
No abstract available

Keywords: Editorials; aortic aneurysm; coronary vessels; diagnosis; dissection; genetics.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Tarr et al. in this Journal present new genomic data to inform the genomic architecture of spontaneous coronary artery dissection (SCAD), revealing a relatively high proportion of clinically actionable pathogenic or likely pathogenic (P/LP) variants in known connective tissue disease (CTD) genes. These results reveal a shared genetic mechanism between SCAD, CTD, and hereditary aortopathy which raises important questions for the genetic cardiologist and genetic counselor. Created with Biorender.com.
See this image and copyright information in PMC

Comment on

  • Exploring the Genetic Architecture of Spontaneous Coronary Artery Dissection Using Whole-Genome Sequencing.
    Tarr I, Hesselson S, Iismaa SE, Rath E, Monger S, Troup M, Mishra K, Wong CMY, Hsu PC, Junday K, Humphreys DT, Adlam D, Webb TR, Baranowska-Clarke AA, Hamby SE, Carss KJ, Samani NJ, Bax M, McGrath-Cadell L, Kovacic JC, Dunwoodie SL, Fatkin D, Muller DWM, Graham RM, Giannoulatou E. Tarr I, et al. Circ Genom Precis Med. 2022 Aug;15(4):e003527. doi: 10.1161/CIRCGEN.121.003527. Epub 2022 May 18. Circ Genom Precis Med. 2022. PMID: 35583931 Free PMC article.

References

    1. Musunuru K, Hershberger RE, Day SM, Klinedinst NJ, Landstrom AP, Parikh VN, Prakash S, Semsarian C, Sturm AC, American Heart Association Council on G, Precision M, Council on Arteriosclerosis T, Vascular B, Council on C, Stroke N and Council on Clinical C. Genetic Testing for Inherited Cardiovascular Diseases: A Scientific Statement From the American Heart Association. Circ Genom Precis Med. 2020;13:e000067. - PubMed
    1. Nikpay M, Goel A, Won HH, Hall LM, Willenborg C, Kanoni S, Saleheen D, Kyriakou T, Nelson CP, Hopewell JC, et al. A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease. Nat Genet. 2015;47:1121–1130. - PMC - PubMed
    1. Schunkert H, Konig IR, Kathiresan S, Reilly MP, Assimes TL, Holm H, Preuss M, Stewart AF, Barbalic M, Gieger C, et al. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet. 2011;43:333–8. - PMC - PubMed
    1. van der Harst P, Verweij N. Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease. Circ Res. 2018;122:433–443. - PMC - PubMed
    1. Aragam KG, Jiang T, Goel A, Kanoni S, Wolford BN, Weeks EM, Wang M, Hindy G, Zhou W, Grace C, et al. Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants. medRxiv. 2021:2021.05.24.21257377. - PMC - PubMed

Supplementary concepts