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. 2022 Aug 18;17(8):e0272258.
doi: 10.1371/journal.pone.0272258. eCollection 2022.

Effect of timing of coronary revascularization in patients with post-infectious myocardial infarction

Chuan-Tsai Tsai  1   2 , Ya-Wen Lu  1   2 , Ruey-Hsing Chou  1   2   3   4 , Chin-Sung Kuo  2   4   5 , Po-Hsun Huang  1   2   3   4 , Cheng-Hsueh Wu  1   2   3 , Shao-Sung Huang  1   2
Affiliations

Effect of timing of coronary revascularization in patients with post-infectious myocardial infarction

Chuan-Tsai Tsai et al. PLoS One. .

Abstract

Objectives: Acute infection is a well-known provocative factor of acute myocardial infarction (AMI). Prognosis is worse when it is associated with sepsis. Coronary revascularization is reported to provide benefit in these patients; however, the optimal timing remains uncertain.

Methods: This retrospective study was performed at a tertiary center in Taipei from January 2010 to December 2017. 1931 patients received coronary revascularization indicated for AMI. Among these, 239 patients were hospitalized for acute infection but later developed AMI. Patients with either an ST-elevation myocardial infarct or the absence of obstructive coronary artery disease were excluded. Revascularization was performed via either percutaneous coronary intervention (PCI) or coronary artery bypass graft (CABG). We defined early and delayed revascularization groups if it was performed within or after 24 hours of the diagnosis of AMI, respectively. We evaluated whether the timing of revascularization altered 30-day and one-year all-cause mortality.

Results: At one month, 24 (26%) patients died in early revascularization group and 32 (22%) patients in delayed revascularization group. At one year, 40 (43%) and 59 (40%) patients died on early and delayed revascularization groups respectively. Early revascularization did not result in lower 30-day all-cause mortality (P = 0.424), and one-year all-cause mortality (Hazard ratio (HR): 0.935; 95% confidence interval (CI): 0.626-1.397, P = 0.742) than delay revascularization.

Conclusions: Timing of coronary revascularization of post infectious acute coronary syndrome may be arranged according to individual risk category as those without sepsis.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Flowchart of patient selection.
Fig 2
Fig 2. Kaplan-Meier survival curve of all-cause mortality of patients with post infectious ACS according to timing of revascularization.
(A) 30-day all-cause mortality (B) one-year all-cause mortality.
See this image and copyright information in PMC

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References

    1. https://www.who.int/en/news-room/fact-sheets/detail/cardiovascular-disea....
    1. Thygesen K, Alpert JS, Jaffe AS, Simoons ML, Chaitman BR, White HD, et al.. Third universal definition of myocardial infarction. Journal of the American College of Cardiology. 2012;60(16):1581–98. Epub 2012/09/11. doi: 10.1016/j.jacc.2012.08.001 . - DOI - PubMed
    1. Smeeth L, Thomas SL, Hall AJ, Hubbard R, Farrington P, Vallance P. Risk of myocardial infarction and stroke after acute infection or vaccination. The New England journal of medicine. 2004;351(25):2611–8. Epub 2004/12/17. doi: 10.1056/NEJMoa041747 . - DOI - PubMed
    1. Cuervo G, Viasus D, Carratala J. Acute Myocardial Infarction after Laboratory-Confirmed Influenza Infection. The New England journal of medicine. 2018;378(26):2540. Epub 2018/06/29. doi: 10.1056/NEJMc1805679 . - DOI - PubMed
    1. Vallance P, Collier J, Bhagat K. Infection, inflammation, and infarction: does acute endothelial dysfunction provide a link? Lancet. 1997;349(9062):1391–2. Epub 1997/05/10. doi: 10.1016/S0140-6736(96)09424-X . - DOI - PubMed

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