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Comment
. 2022 Aug 17;110(16):2513-2515.
doi: 10.1016/j.neuron.2022.07.008.

Protecting against summation of pain

Daniela Mauceri  1 , Rohini Kuner  2
Affiliations
Free article
Comment

Protecting against summation of pain

Daniela Mauceri et al. Neuron. .
Free article

Abstract

Temporal summation in the spinal cord is linked to pathological pain. In a translational genetic association study in this issue of Neuron, Trendafilova et al. (2022) identify the sodium-calcium exchanger 3 as a negative regulator of temporal summation and hypersensitivity via its modulation of calcium homeostasis.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

  • Sodium-calcium exchanger-3 regulates pain "wind-up": From human psychophysics to spinal mechanisms.
    Trendafilova T, Adhikari K, Schmid AB, Patel R, Polgár E, Chisholm KI, Middleton SJ, Boyle K, Dickie AC, Semizoglou E, Perez-Sanchez J, Bell AM, Ramirez-Aristeguieta LM, Khoury S, Ivanov A, Wildner H, Ferris E, Chacón-Duque JC, Sokolow S, Saad Boghdady MA, Herchuelz A, Faux P, Poletti G, Gallo C, Rothhammer F, Bedoya G, Zeilhofer HU, Diatchenko L, McMahon SB, Todd AJ, Dickenson AH, Ruiz-Linares A, Bennett DL. Trendafilova T, et al. Neuron. 2022 Aug 17;110(16):2571-2587.e13. doi: 10.1016/j.neuron.2022.05.017. Epub 2022 Jun 14. Neuron. 2022. PMID: 35705078 Free PMC article.

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