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. 2022 Summer;40(3):380-384.
doi: 10.2337/cd21-0118.

Impact of Insulin-Derived Amyloidosis on Glycemic Control and Insulin Dosing

Aaron Estep  1 , Jarrod Uhrig  2 , Curtis Bower  3 , Robert Jarrett  4   5
Affiliations

Impact of Insulin-Derived Amyloidosis on Glycemic Control and Insulin Dosing

Aaron Estep et al. Clin Diabetes. 2022 Summer.
No abstract available

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Figures

FIGURE 1
FIGURE 1
Ultrasound imaging showing hypoechoic mass with irregular borders.
FIGURE 2
FIGURE 2
Computed tomography scan of abdomen and pelvis without contrast showing subcutaneous mass.
FIGURE 3
FIGURE 3
Congo-red stain of tissue sample showing characteristic apple-green birefringence seen with amyloid deposits.
See this image and copyright information in PMC

References

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    1. Nakamura M, Misumi Y, Nomura T, et al. . Extreme adhesion activity of amyloid fibrils induces subcutaneous insulin resistance. Diabetes 2019;68:609–616 - PubMed
    1. Samlaska C, Reber S, Murry T. Insulin-derived amyloidosis: the insulin ball, amyloidoma. JAAD Case Rep 2020;6:351–353 - PMC - PubMed
    1. Tanio N, Nozaki T, Matsusako M, Starkey J, Suzuki K. Imaging characteristics of subcutaneous amyloid deposits in diabetic patients: the “insulin ball.” Skeletal Radiol 2018;47:85–92 - PubMed
    1. Shiba M, Kitazawa T. Progressive insulin-derived amyloidosis in a patient with type 2 diabetes. Case Reports Plast Surg Hand Surg 2016;3:73–76 - PMC - PubMed