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Editorial
. 2022 Sep 1;50(9):1396-1398.
doi: 10.1097/CCM.0000000000005613. Epub 2022 Aug 15.

Sex, Renin Angiotensin System Inhibitors, and COVID-19 Severity: Biologic Divergence or Healthcare Disparity?

Daniel E Leisman  1   2 , Emily E Moin  2   3
Affiliations
Editorial

Sex, Renin Angiotensin System Inhibitors, and COVID-19 Severity: Biologic Divergence or Healthcare Disparity?

Daniel E Leisman et al. Crit Care Med. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors have disclosed that they do not have any potential conflicts of interest.

Comment on

  • Renin-Angiotensin System Pathway Therapeutics Associated With Improved Outcomes in Males Hospitalized With COVID-19.
    Rocheleau GLY, Lee T, Mohammed Y, Goodlett D, Burns K, Cheng MP, Tran K, Sweet D, Marshall J, Slutsky AS, Murthy S, Singer J, Patrick DM, Du B, Peng Z, Lee TC, Boyd JH, Walley KR, Lamontagne F, Fowler R, Winston BW, Haljan G, Vinh DC, McGeer A, Maslove D, Patrigeon SP, Mann P, Donohoe K, Hernandez G, Russell JA; for ARBs CORONA I Investigators. Rocheleau GLY, et al. Crit Care Med. 2022 Sep 1;50(9):1306-1317. doi: 10.1097/CCM.0000000000005589. Epub 2022 May 18. Crit Care Med. 2022. PMID: 35607951 Free PMC article.

References

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    1. Imai Y, Kuba K, Rao S, et al. : Angiotensin-converting enzyme 2 protects from severe acute lung failure. Nature 2005; 436:112–116 - PMC - PubMed
    1. Leisman DE, Mehta A, Thompson BT, et al. : Alveolar, endothelial, and organ injury marker dynamics in severe COVID-19. Am J Respir Crit Care Med 2022; 205:507–519 - PMC - PubMed
    1. Ozkan S, Cakmak F, Konukoglu D, et al. : Efficacy of serum angiotensin II levels in prognosis of patients with coronavirus disease 2019. Crit Care Med 2021; 49:e613–e623 - PubMed
    1. Akin S, Schriek P, van Nieuwkoop C, et al. : A low aldosterone/renin ratio and high soluble ACE2 associate with COVID-19 severity. J Hypertens 2022; 40:606–614 - PMC - PubMed

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