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Comment
. 2022 Sep 1;50(9):e731-e732.
doi: 10.1097/CCM.0000000000005581. Epub 2022 Aug 15.

Proof of Concept, Feasibility, and Efficacy Trials

Sudha Chandelia  1
Affiliations
Comment

Proof of Concept, Feasibility, and Efficacy Trials

Sudha Chandelia. Crit Care Med. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

Dr. Chandelia has disclosed that she does not have any potential conflicts of interest.

Comment in

  • The authors reply.
    de Vries HJ, de Grooth HJ, Heunks LM. de Vries HJ, et al. Crit Care Med. 2022 Sep 1;50(9):e732-e734. doi: 10.1097/CCM.0000000000005598. Epub 2022 Aug 15. Crit Care Med. 2022. PMID: 35984069 No abstract available.

Comment on

References

    1. de Vries HJ, Jonkman AH, de Grooth HJ, et al.: Lung- and diaphragm-protective ventilation by titrating inspiratory support to diaphragm effort: A randomized clinical trial. Crit Care Med 2022; 50:192–203
    1. Singal AG, Higgins PD, Waljee AK: A primer on effectiveness and efficacy trials. Clin Transl Gastroenterol 2014; 5:e45
    1. Li QH, Deng Q, Ting N: Proof of concept: Drug selection? Or dose selection? Thoughts on multiplicity issues. Ther Innov Regul Sci 2021; 55:1001–1005
    1. Eldridge SM, Lancaster GA, Campbell MJ, et al.: Defining feasibility and pilot studies in preparation for randomised controlled trials: Development of a conceptual framework. PLoS One 2016; 11:e0150205
    1. Sainani KL: Making sense of intention-to-treat. PM R 2010; 2:209–213

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