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Review
. 2022 Oct;311(1):9-25.
doi: 10.1111/imr.13126. Epub 2022 Aug 19.

Neuroimmune signaling at the brain borders

Natalie M Frederick  1 , Gabriel A Tavares  1 , Antoine Louveau  1   2   3
Affiliations
Review

Neuroimmune signaling at the brain borders

Natalie M Frederick et al. Immunol Rev. 2022 Oct.

Abstract

The central nervous system (CNS) has been viewed as an immunologically privileged site, but emerging works are uncovering a large array of neuroimmune interactions primarily occurring at its borders. CNS barriers sites host diverse population of both innate and adaptive immune cells capable of, directly and indirectly, influence the function of the residing cells of the brain parenchyma. These structures are only starting to reveal their role in controlling brain function under normal and pathological conditions and represent an underexplored therapeutic target for the treatment of brain disorders. This review will highlight the development of the CNS barriers to host neuro-immune interactions and emphasize their newly described roles in neurodevelopmental, neurological, and neurodegenerative disorders, particularly for the meninges.

Keywords: blood brain barrier; choroid plexus; dura; lymphatic; meninges; neurodegeneration; neurodevelopment; neuroimmunology.

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References

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