Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Sep 1;75(3):e49-e52.
doi: 10.1097/MPG.0000000000003546. Epub 2022 Jun 23.

Serrated Polyposis Syndrome in a Young Adolescent Patient

Victor L Fox  1 , Inbar S Spofford  2 , Brian D Crompton  3 , Mathew B Yurgelun  4 , Craig W Lillehei  5 , Jeffrey D Goldsmith  6
Affiliations

Serrated Polyposis Syndrome in a Young Adolescent Patient

Victor L Fox et al. J Pediatr Gastroenterol Nutr. .

Abstract

Serrated polyps are pathological neoplastic lesions in the colon with subtle gross morphology leading to underreporting during colonoscopy. While detection rates are increasing in average-risk adult screening colonoscopy, the rate of detection during pediatric colonoscopy is unknown. Serrated polyposis syndrome is characterized by the presence of multiple serrated polyps in the colon and an increased risk of developing colorectal cancer. Cancer prevention relies on early recognition, endoscopic clearance of all polyps > 5 mm, and continued interval surveillance or prophylactic colectomy. We report the diagnosis and management of serrated polyposis syndrome in a young adolescent patient and highlight the subtle features of serrated polyps that may go unrecognized leading to underreporting in childhood.

PubMed Disclaimer

Conflict of interest statement

The authors report no conflicts of interest.

References

    1. Rivero-Sanchez L, Lopez-Ceron M, Carballal S, et al. Reassessment colonoscopy to diagnose serrated polyposis syndrome in a colorectal cancer screening population. Endoscopy 2017;49:44–53.
    1. Rosty C, Brosens LA, Dekker E, et al., Serrated polyposis. 5th ed. Lyon: International Agency for Research on Cancer, 2019.
    1. IJspeert J, Bevan R, Senore C, et al. Detection rate of serrated polyps and serrated polyposis syndrome in colorectal cancer screening cohorts: a European overview. Gut 2017;66:1225–32.
    1. Hewett DG, Kaltenbach T, Sano Y, et al. Validation of a simple classification system for endoscopic diagnosis of small colorectal polyps using narrow-band imaging. Gastroenterology 2012;143:599–607.e1.
    1. Rosty C, Buchanan DD, Walsh MD, et al. Phenotype and polyp landscape in serrated polyposis syndrome: a series of 100 patients from genetics clinics. Am J Surg Pathol 2012;36:876–82.