Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Oct:132:102874.
doi: 10.1016/j.jaut.2022.102874. Epub 2022 Aug 5.

Autoimmune hepatitis following COVID-19 vaccination

Arantzazu Izagirre  1 , Teresa Arzallus  2 , Maddi Garmendia  3 , Silvia Torrente  2 , Agustin Castiella  2 , Eva María Zapata  2
Affiliations

Autoimmune hepatitis following COVID-19 vaccination

Arantzazu Izagirre et al. J Autoimmun. 2022 Oct.
No abstract available

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Immunohistochemistry staining with CD38 shows many CD38+ plasma cells. These cells are one of the most characteristic histological findings in AIH.
Fig. 2
Fig. 2
Portal tract showing mild ductular proliferation accompanied by this prominent mixed inflammatory cell infiltrate. The inflammation is located mainly in the perifery of the portal tract where interface and lobular can be observed. Portal fibroinflammatory expansion can be easily recognized.
Fig. 3
Fig. 3
Higher magnification of the portal tract, where inflammatory damage can be observed. Lymphocytes, neutrophils and many plasma cells (CD38+, figure 1 caption) with scattered eosinophils can be recognized. A few neutrophils may be permeating ductal epithelium.
See this image and copyright information in PMC

References

    1. Vojdani A., Kharrazian D. Potential antigenic cross-reactivity between SARS-CoV-2 and human tissue with a possible link to an increase in autoimmune diseases. Clin. Immunol. 2020 Aug 1;217 - PMC - PubMed
    1. EASL clinical practice guidelines: autoimmune hepatitis. J. Hepatol. 2015 Oct 1;63(4):971–1004. - PubMed
    1. Torrente S., Castiella A., Garmendia M., Zapata E. Probable autoimmune hepatitis reactivated after COVID-19 vaccination. Gastroenterol. Hepatol. 2021 Oct 28;(1):115–116. S0210-5705(21)00302-2. - PMC - PubMed
    1. Efe C., Kulkarni A.V., Terziroli Beretta-Piccoli B., Magro B., Friedrich Stättermayer A., Cengiz M., et al. Liver injury after SARS-CoV-2 vaccination Features of immune-mediated hepatitis, role of corticosteroid therapy and outcome. Hepatology [Internet]. [cited 2022 Jul 5];n/a(n/a) https://onlinelibrary.wiley.com/doi/abs/10.1002/hep.32572 Available from: - DOI - PMC - PubMed
    1. Bril F., Al Diffalha S., Dean M., Fettig D.M. Autoimmune hepatitis developing after coronavirus disease 2019 (COVID-19) vaccine: causality or casualty? J. Hepatol. 2021 Jul;75(1):222–224. - PMC - PubMed

MeSH terms

Substances