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Comment
. 2022 Aug 18;82(16):2922-2924.
doi: 10.1016/j.molcel.2022.07.015.

Enhancers have more cofactor specificity than we think: A potential new way to classify enhancers based on their functional cofactor requirements

Blanca Pijuan-Sala  1 , Eileen E M Furlong  2
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Comment

Enhancers have more cofactor specificity than we think: A potential new way to classify enhancers based on their functional cofactor requirements

Blanca Pijuan-Sala et al. Mol Cell. .
Free article

Abstract

By systematically assessing the effects of depleting eight cofactors on enhancer activity, Neumayr et al. (2022) found that different enhancers have different requirements for some perceived universal cofactors. While some cofactors influence enhancer strength, others affect enhancer-promoter specificity.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

  • Differential cofactor dependencies define distinct types of human enhancers.
    Neumayr C, Haberle V, Serebreni L, Karner K, Hendy O, Boija A, Henninger JE, Li CH, Stejskal K, Lin G, Bergauer K, Pagani M, Rath M, Mechtler K, Arnold CD, Stark A. Neumayr C, et al. Nature. 2022 Jun;606(7913):406-413. doi: 10.1038/s41586-022-04779-x. Epub 2022 Jun 1. Nature. 2022. PMID: 35650434 Free PMC article.

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