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. 2022 Oct;10(8):888-897.
doi: 10.1002/ueg2.12289. Epub 2022 Aug 19.

Worldwide prevalence and burden of gastroparesis-like symptoms as defined by the United European Gastroenterology (UEG) and European Society for Neurogastroenterology and Motility (ESNM) consensus on gastroparesis

I-Hsuan Huang  1   2 , Jolien Schol  1 , Rutaba Khatun  3 , Florencia Carbone  1   4 , Karen Van den Houte  1 , Esther Colomier  1   5 , Lukas Michaja Balsiger  1 , Hans Törnblom  5 , Tim Vanuytsel  1   4 , Elias Sundelin  6 , Magnus Simrén  7   8 , Olafur S Palsson  7 , Shrikant I Bangdiwala  3   9 , Ami D Sperber  10 , Jan Tack  1   4
Affiliations

Worldwide prevalence and burden of gastroparesis-like symptoms as defined by the United European Gastroenterology (UEG) and European Society for Neurogastroenterology and Motility (ESNM) consensus on gastroparesis

I-Hsuan Huang et al. United European Gastroenterol J. 2022 Oct.

Abstract

Background/objectives: The global epidemiology of gastroparesis is unknown. The European UEG and European Society for Neurogastroenterology and motility consensus defines Gastroparesis as a condition characterized by delayed gastric emptying in the absence of mechanical obstruction, with a symptom pattern of nausea and/or vomiting and overlapping postprandial distress syndrome (PDS). Real-world evidence of this gastroparesis-like symptom pattern is a crucial step in understanding the epidemiology of gastroparesis.

Methods: In the Rome Foundation Global Epidemiology Study, 54,127 respondents from 26 countries completed the Rome IV Diagnostic Questionnaire and variables associated with disorders of gut-brain interaction via Internet. We selected subjects with gastroparesis-like symptoms (GPLS) (nausea and/or vomiting ≥1 day/week and simultaneous PDS). Patients reporting organic gastrointestinal disease, or fulfilling criteria for self-induced vomiting, cyclic vomiting or cannabinoid hyperemesis syndrome were excluded. We determined prevalence, associated comorbidities, quality of life (QoL) (PROMIS Global-10), symptoms of anxiety and depression (PHQ-4), somatic symptoms (PHQ-12), and healthcare utilization.

Results: The global prevalence of GPLS was 0.9% overall and 1.3% among diabetic individuals. Subjects with GPLS showed frequent overlapping of epigastric pain syndrome and irritable bowel syndrome. Subjects with GPLS had significantly lower body mass index, QoL, more non-gastrointestinal somatic complaints, symptoms of anxiety and depression, higher medication usage and doctor visits in the overall and diabetic population, compared to subjects without these symptoms.

Conclusions: GPLS are common worldwide and more common in diabetic patients. The symptom complex is associated with multiple aspects of illness and an increased healthcare consumption.

Keywords: gastroparesis; gastroparesis-like symptoms; prevalence.

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Conflict of interest statement

The authors disclose no conflicts.

Figures

FIGURE 1
FIGURE 1
Prevalence of gastroparesis‐like symptoms (% and 95% CI) in the general population in each country
FIGURE 2
FIGURE 2
Prevalence of gastroparesis‐like symptoms (% and 95% CI) in the non‐diabetic subjects in each country
FIGURE 3
FIGURE 3
Prevalence of gastroparesis‐like symptoms (% and 95% CI) in the diabetic subjects in each country
See this image and copyright information in PMC

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