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. 2022 Aug 20;22(1):493.
doi: 10.1186/s12887-022-03543-4.

Morbidity and psychomotor development of offspring of women with gestational diabetes: a 5-year follow-up

Vendula Bartáková  1 , Beáta Barátová  2   3 , Katarína Chalásová  2 , Petr Janků  4 , Kateřina Kaňková  2
Affiliations

Morbidity and psychomotor development of offspring of women with gestational diabetes: a 5-year follow-up

Vendula Bartáková et al. BMC Pediatr. .

Abstract

Background: Gestational diabetes mellitus (GDM) represents a risk factor for both mother and her offspring in a short-term (perinatal morbidity) and long-term horizon (postpartum diabetes or foetal programming). Several studies focused at peri/postnatal outcomes of GDM mother´s offspring, however relatively few (and none in Czech population) were designed as prospective. The aim of the study was to ascertain eventual anthropometric and developmental abnormalities and/or morbidity in offspring of GDM mothers compare to controls in a 5-year follow-up using a parent-reported parameters related to psychomotor development and common paediatric morbidities including a sub-study of offspring of GDM mothers experiencing adverse perinatal outcomes.

Methods: A 5 year follow up study of offspring of GDM mothers (n = 26) vs those with a normal pregnancy (n = 63). An electronic questionnaire was used to obtain the parameters (such as growth, psychomotor development, vaccination, morbidity history etc.) available to parents from the parent-held infant health record. Data on pregnancy and delivery were available from the previous study.

Results: Offspring of GDM mothers had delayed psychomotor development in early childhood, but in 5 years of age they seemed to gradually achieve results of a control group. Children with macrosomia had a higher percentile of weight-for-height and were significantly more frequently ill than those with a normal birth weight. Offspring of obese mothers had worse verbal language skills in early childhood and a higher percentile of weight-for-height.

Conclusion: Maternal gestational diabetes and obesity can be considered an important determinant of postnatal offspring development and health status, which further advocates for broader implementation of preventive strategies.

Keywords: Gestational diabetes mellitus; Obesity; Offspring; Pregnancy; Prospective study.

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Conflict of interest statement

None declared.

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