Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2022 Aug;12(8):e1027.
doi: 10.1002/ctm2.1027.

Chaperonin-containing TCP-1 subunit 2-mediated aggrephagy: A potential target for treating neurodegeneration

Xueshen Chen  1 , Min Zhang  1
Affiliations
Comment

Chaperonin-containing TCP-1 subunit 2-mediated aggrephagy: A potential target for treating neurodegeneration

Xueshen Chen et al. Clin Transl Med. 2022 Aug.
No abstract available

PubMed Disclaimer

Figures

FIGURE 1
FIGURE 1
Chaperonin‐containing TCP‐1 subunit 2 (CCT2)’s dual function in preventing protein aggregation and removing protein aggregates. CCT2 can function as a component of the TRiC complex to suppress protein misfolding and aggregation; also, it can act as a monomeric autophagy receptor to facilitate the clearance of solid protein aggregates by selective autophagy
FIGURE 2
FIGURE 2
Chaperonin‐containing TCP‐1 subunit 2 (CCT2) as a potential target against neurodegenerative diseases caused by protein aggregation. Protein aggregation is a pathological feature of several neurodegenerative diseases. The function of CCT2 in clearing aggregation‐prone proteins through selective autophagy makes it a potential target for the treatment of neurodegenerative diseases
See this image and copyright information in PMC

Comment on

References

    1. Brehme M, Voisine C, Rolland T, et al. A chaperome subnetwork safeguards proteostasis in aging and neurodegenerative disease. Cell Rep. 2014;9:1135‐1150. - PMC - PubMed
    1. Budd Haeberlein SL, Harris TJ. Promising targets for the treatment of neurodegenerative diseases. Clin Pharmacol Ther. 2015;98:492‐501. - PubMed
    1. Davis AA, Leyns CEG, Holtzman, DM . Intercellular spread of protein aggregates in neurodegenerative disease. Annu Rev Cell Dev Biol. 2018;34:545‐568. - PMC - PubMed
    1. Jin M, Liu C, Han W, Cong Y. TRiC/CCT chaperonin: Structure and function. Subcell Biochem. 2019;93:625‐654. - PubMed
    1. Lamark T, Johansen T. Aggrephagy: Selective disposal of protein aggregates by macroautophagy. Int J Cell Biol. 2012;2012:736905. - PMC - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources