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Comment
. 2022 Nov;45(11):794-795.
doi: 10.1016/j.tins.2022.08.002. Epub 2022 Aug 18.

Glycine-bound NMDA receptors are stretch-activated

Swetha E Murthy  1
Affiliations
Comment

Glycine-bound NMDA receptors are stretch-activated

Swetha E Murthy. Trends Neurosci. 2022 Nov.

Abstract

In a recent study, Belin et al. demonstrated that glycine-bound NMDA receptors can be activated by mechanical forces in the absence of the neurotransmitter glutamate. The stretch-gated receptor exhibits biophysical properties similar to those of glutamate-gated receptors. These findings reveal that glycine-bound NMDA receptors could behave as mechanosensors in central nervous system (CNS) physiology.

Keywords: NMDA receptors; mechanically activated ion channels; mechanosensation.

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Conflict of interest statement

Declaration of interests The author declares no competing interests.

Comment on

  • Membrane Stretch Gates NMDA Receptors.
    Belin S, Maki BA, Catlin J, Rein BA, Popescu GK. Belin S, et al. J Neurosci. 2022 Jul 20;42(29):5672-5680. doi: 10.1523/JNEUROSCI.0350-22.2022. Epub 2022 Jun 15. J Neurosci. 2022. PMID: 35705487 Free PMC article.

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