More Than Pharmacokinetics: Transporters in Clinical Pharmacology

Affiliations

¹ Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, California, USA.
² Office of Clinical Pharmacology, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA.

Editorial

Kathleen M Giacomini et al. Clin Pharmacol Ther. 2022 Sep.

. 2022 Sep;112(3):423-426.

doi: 10.1002/cpt.2710.

¹ Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, California, USA.
² Office of Clinical Pharmacology, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA.

No abstract available

Comment on

Regulation of Drug Transport Proteins-From Mechanisms to Clinical Impact: A White Paper on Behalf of the International Transporter Consortium.
Brouwer KLR, Evers R, Hayden E, Hu S, Li CY, Meyer Zu Schwabedissen HE, Neuhoff S, Oswald S, Piquette-Miller M, Saran C, Sjöstedt N, Sprowl JA, Stahl SH, Yue W. Brouwer KLR, et al. Clin Pharmacol Ther. 2022 Sep;112(3):461-484. doi: 10.1002/cpt.2605. Epub 2022 May 24. Clin Pharmacol Ther. 2022. PMID: 35390174 Free PMC article. Review.

1. International Transporter Consortium (ITC) <https://www.itc-transporter.org/>
1. RESOLUTE Consortium <https://re-solute.eu/>
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1. Giacomini, K.M. et al. New and emerging research on SLC and ABC transporters in drug discovery and development: outlook from the international transporter consortium. Clin. Pharmacol. Ther. 112, 540-561 (2022).
1. Chu, X. et al. Clinical probes and endogenous biomarkers as substrates for transporter drug-drug interaction evaluation: perspectives from the international transporter consortium. Clin. Pharmacol. Ther. 104, 836-864 (2018).