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Review
. 2023 Jan;15(1):e1842.
doi: 10.1002/wnan.1842. Epub 2022 Aug 21.

Tumor microenvironment-regulating nanomedicine design to fight multi-drug resistant tumors

Qinqin Xu  1 , Xinyue Lan  1   2 , Huimin Lin  1 , Qiye Xi  1 , Manchun Wang  1 , Xiaolong Quan  1 , Guangyu Yao  2 , Zhiqiang Yu  3 , Yongxia Wang  3 , Meng Yu  1
Affiliations
Review

Tumor microenvironment-regulating nanomedicine design to fight multi-drug resistant tumors

Qinqin Xu et al. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2023 Jan.

Abstract

The tumor microenvironment (TME) is a very cunning system that enables tumor cells to escape death post-traditional antitumor treatments through the comprehensive effect of different factors, thereby leading to drug resistance. Deep insights into TME characteristics and tumor resistance encourage the construction of nanomedicines that can remodel the TME against drug resistance. Tremendous interest in combining TME-regulation measurement with traditional tumor treatment to fight multidrug-resistant tumors has been inspired by the increasing understanding of the role of TME reconstruction in improving the antitumor efficiency of drug-resistant tumor therapy. This review focuses on the underlying relationships between specific TME characteristics (such as hypoxia, acidity, immunity, microorganisms, and metabolism) and drug resistance in tumor treatments. The exciting antitumor activities strengthened by TME regulation are also discussed in-depth, providing solutions from the perspective of nanomedicine design. This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease Nanotechnology Approaches to Biology > Nanoscale Systems in Biology.

Keywords: TME reconstruction; drug-resistance; hypoxia; nanomedicine; tumor microenvironment.

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References

FURTHER READING
    1. Martin, J. D., Miyazaki, T., & Cabral, H. (2021). Remodeling tumor microenvironment with nanomedicines. WIREs Nanomedicine and Nanobiotechnology, 13, e1730. https://doi.org/10.1002/wnan.1730
    1. Qiao, Y., Wan, J., Zhou, L., Ma, W., Yang, Y., Luo, W., Yu, Z., & Wang, H. (2019). Stimuli-responsive nanotherapeutics for precision drug delivery and cancer therapy. WIREs Nanomedicine and Nanobiotechnology, 11, e1527. https://doi.org/10.1002/wnan.1527
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