Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Jul 19;14(7):e27041.
doi: 10.7759/cureus.27041. eCollection 2022 Jul.

Diagnostic Utility of Cytokeratin 17 Expression in Oral Squamous Cell Carcinoma: A Review

Ankita Gyanchandani  1 , Samarth Shukla  1 , Sunita Vagha  1 , Sourya Acharaya  2 , Ravindra P Kadu  1
Affiliations
Review

Diagnostic Utility of Cytokeratin 17 Expression in Oral Squamous Cell Carcinoma: A Review

Ankita Gyanchandani et al. Cureus. .

Abstract

One of the most common oral malignancies is oral squamous cell carcinoma (OSCC). Although the prevalence of oral cancer varies worldwide, it is generally agreed that the oral cavity is a common anatomical site for cancer, depending primarily on the country (and even particular region in some countries) and gender of the patients. Finding diagnostic markers for OSCC is critical for early diagnosis and personalised treatment of patients. Because they are overexpressed in OSCC relative to normal mucosa, cytokeratins (CKs), intermediate filaments of the cytoskeletons, are possibilities for diagnostic markers of OSCC. CK17 should be targeted as a diagnostic marker for OSCC among the CKs, as multiple other CKs have been linked to the disease. This study aims to assess the immuno-histochemistry expression of CK17 and to investigate whether there is a link between CK17 and OSCC differentiation.

Keywords: broders grading; ck 17; histological grading; immunohistochemistry; oral squamous cell carcinoma.

PubMed Disclaimer

Conflict of interest statement

The authors have declared that no competing interests exist.

Similar articles

See all similar articles

Cited by

References

    1. Current aspects on oral squamous cell carcinoma. Markopoulos AK. Open Dent J. 2012;6:126–130. - PMC - PubMed
    1. Oral squamous cell carcinoma: etiology, pathogenesis and prognostic value of genomic alterations. Mehrotra R, Yadav S. Indian J Cancer. 2006;43:60–66. - PubMed
    1. Prevalence of oral cancer in India. Varshitha A. https://www.jpsr.pharmainfo.in/Documents/Volumes/vol7Issue10/jpsr0710150... Pharm Sci Res. 2015;7:845–848.
    1. Association of cytokeratin 17 expression with differentiation in oral squamous cell carcinoma. Kitamura R, Toyoshima T, Tanaka H, et al. J Cancer Res Clin Oncol. 2012;138:1299–1310. - PMC - PubMed
    1. Histopathological grading systems in oral squamous cell carcinoma: a review. Bhargava A, Saigal S, Chalishazer M. https://www.ispcd.org/userfiles/rishabh/jioh-02-04-001.pdf J Int Oral Health. 2010; 2:1–10.

LinkOut - more resources