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Review
. 2022 Jul 19;14(7):e27041.
doi: 10.7759/cureus.27041. eCollection 2022 Jul.

Diagnostic Utility of Cytokeratin 17 Expression in Oral Squamous Cell Carcinoma: A Review

Ankita Gyanchandani  1 , Samarth Shukla  1 , Sunita Vagha  1 , Sourya Acharaya  2 , Ravindra P Kadu  1
Affiliations
Review

Diagnostic Utility of Cytokeratin 17 Expression in Oral Squamous Cell Carcinoma: A Review

Ankita Gyanchandani et al. Cureus. .

Abstract

One of the most common oral malignancies is oral squamous cell carcinoma (OSCC). Although the prevalence of oral cancer varies worldwide, it is generally agreed that the oral cavity is a common anatomical site for cancer, depending primarily on the country (and even particular region in some countries) and gender of the patients. Finding diagnostic markers for OSCC is critical for early diagnosis and personalised treatment of patients. Because they are overexpressed in OSCC relative to normal mucosa, cytokeratins (CKs), intermediate filaments of the cytoskeletons, are possibilities for diagnostic markers of OSCC. CK17 should be targeted as a diagnostic marker for OSCC among the CKs, as multiple other CKs have been linked to the disease. This study aims to assess the immuno-histochemistry expression of CK17 and to investigate whether there is a link between CK17 and OSCC differentiation.

Keywords: broders grading; ck 17; histological grading; immunohistochemistry; oral squamous cell carcinoma.

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Conflict of interest statement

The authors have declared that no competing interests exist.

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