Comparative Study
Comparison of the urate lowering effects of allopurinol and diflunisal
- PMID: 3599002
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Comparative Study
Comparison of the urate lowering effects of allopurinol and diflunisal
J Rheumatol.
1987 Apr.
Abstract
The urate lowering effect of diflunisal, a fluorinated salicylate with an antiinflammatory action, was compared with that of allopurinol in a crossover study. When patients took diflunisal the mean serum urate was significantly greater than on allopurinol but still was within the optimal range in 6 of 8 patients studied. This effect was consistent with its uricosuric action. No inhibition of xanthine oxidase activity by diflunisal was found. Diflunisal could be particularly useful in patients who require a drug with both a uricosuric and an antiinflammatory effect.
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