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Case Reports
. 2022 Jul 6:27:61-63.
doi: 10.1016/j.jdcr.2022.06.035. eCollection 2022 Sep.

Amelanotic melanoma in a patient with Hermansky-Pudlak syndrome

Ryan Fan  1 , Margaret S Johnston  1 , Michael F Gowen  1 , William Damsky  1   2 , Ian Odell  1 , James Clune  3 , Matthew D Vesely  1
Affiliations
Case Reports

Amelanotic melanoma in a patient with Hermansky-Pudlak syndrome

Ryan Fan et al. JAAD Case Rep. .
No abstract available

Keywords: BCC, basal cell carcinoma; HPS, Hermansky-Pudlak syndrome; Hermansky-Pudlak syndrome; OCA, oculocutaneous albinism; SCC, squamous cell carcinoma; albinism; melanoma.

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Conflict of interest statement

None disclosed.

Figures

Fig 1
Fig 1
Clinical image of primary melanoma on the left cheek. There is a 1.5-cm pink-red nodule on the left cheek. Note pigmentary dilution of skin and hair as characteristic features of Hermansky-Pudlak syndrome.
Fig 2
Fig 2
Histological images of amelanotic melanoma. A, Hematoxylin & eosin (H&E) staining of melanoma at 40×. B, Melan-A staining at 40×. C, H&E at 400×. Note lack of pigment and numerous mitoses.
See this image and copyright information in PMC

References

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    1. Li W., Hao C.J., Hao Z.H., et al. New insights into the pathogenesis of Hermansky-Pudlak syndrome. Pigment Cell Melanoma Res. 2022;35(3):290–302. doi: 10.1111/pcmr.13030. - DOI - PubMed
    1. Santiago Borrero P.J., Rodríguez-Pérez Y., Renta J.Y., et al. Genetic testing for oculocutaneous albinism type 1 and 2 and Hermansky-Pudlak syndrome type 1 and 3 mutations in Puerto Rico. J Invest Dermatol. 2006;126(1):85–90. doi: 10.1038/sj.jid.5700034. - DOI - PMC - PubMed
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