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Case Reports
. 2022 Aug 16;10(8):e6194.
doi: 10.1002/ccr3.6194. eCollection 2022 Aug.

A primary squamous cell carcinoma of the sigmoid colon in a young patient: A case report and literature review

Mohanad Faisal  1 , Ahmed Abdalhadi  1 , M Zaki Karzoun  2 , Mohamed Aboagla Suliman Mohamed  1 , Mouhammad Zuhair Sharaf Elden  2 , Alaaeldin Shablak  1
Affiliations
Case Reports

A primary squamous cell carcinoma of the sigmoid colon in a young patient: A case report and literature review

Mohanad Faisal et al. Clin Case Rep. .

Abstract

Colon cancer is among the most common types of cancer with adenocarcinomas being the most common type. Herein we report a young patient who presented with primary colonic squamous cell carcinoma without risk factors. To the best of our knowledge, this is the youngest patient with such diagnosis worldwide.

Keywords: colon; oncology; pathology; squamous cell carcinoma; squamous cell carcinomacolon cancer.

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Conflict of interest statement

The authors declare that there is no conflict of interest in the publication of this article.

Figures

FIGURE 1
FIGURE 1
Abdominal CT scan showed thickened sigmoid colon with abdominal lymphadenopathy (arrows).
FIGURE 2
FIGURE 2
(A) The colonic mucosa is intact (left side of the field). The submucosa (right side) is infiltrated by sheets of neoplastic cells (4× magnification). (B) The neoplastic cells are atypical with distinct cell membrane and increased nuclear‐to‐cytoplasmic ratio. Miotic figures and apoptotic bodies are evident (40X magnification). (C) p63 immunohistochemical stain. The neoplastic cells (on the left side of the field) are positive. (D) CDX2 immunohistochemical stain is negative in the tumor cells (left side of the field), while positive in the normal colonic mucosa.
FIGURE 3
FIGURE 3
PET/CT showed a thickening of the distal sigmoid colon and distant lymph nodes in the left supraclavicular region.
See this image and copyright information in PMC

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