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Case Reports
. 2022 Jun 7;35(5):717-718.
doi: 10.1080/08998280.2022.2081914. eCollection 2022.

Delayed diagnosis of adult-onset mastocytosis

Annia Cavazos  1 , Paul Subrt  1 , Jaime A Tschen  1
Affiliations
Case Reports

Delayed diagnosis of adult-onset mastocytosis

Annia Cavazos et al. Proc (Bayl Univ Med Cent). .

Abstract

Urticaria pigmentosa is most frequently observed in children. The associated symptomatology in mastocytosis is vague and not always diagnostic, and Darier's sign is often negative, making the diagnosis challenging. We describe a case of a 61-year-old man with extensive brown papules and macules in different locations of the body that slowly progressed in the last 10 years with a previous anaphylactic reaction after an ant bite. This suggests that urticaria pigmentosa in an adult should be furthered assessed for the possibility of systemic involvement for a correct diagnosis and treatment.

Keywords: Adult-onset mastocytosis; diffuse cutaneous mastocytosis; hymenoptera venom anaphylaxis; urticaria pigmentosa.

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Figures

Figure 1.
Figure 1.
Extensive well-demarcated circular and oval brown papules and macules involving the back with different diameters.
Figure 2.
Figure 2.
Increased numbers of mast cells found in the superficial dermis and hyperpigmentation of the basal layer with scattered lymphocytes and eosinophils.
Figure 3.
Figure 3.
CD-117–positive mast cells in the infiltrate.
See this image and copyright information in PMC

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