. 2019 Dec;10(4):30-34.

doi: 10.1097/cxa.0000000000000069.

Association Study of OPRM1 Gene in a Sample of Schizophrenia Patients With Alcohol Dependence or Abuse

Marie N S Gendy^{1

2}, Clement Zai^{3

4

5}, Bernard Le Foll^{1

6

7

8

2

3

9}, James L Kennedy^{3

4}

Affiliations

¹ Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, 33 Russell Street, Toronto, ON, Canada M5S 2S1.
² Department of Pharmacology, University of Toronto, Medical Science Building, 1 King's College Cir, Toronto, ON, Canada M5S 1A8.
³ Department of Psychiatry, Division of Brain and Therapeutics, University of Toronto, 250 College Street, Toronto, ON, Canada, M5T 1R8.
⁴ Neurogenetics Section, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Centre for Addiction and Mental Health, 250 College St. Toronto, ON, Canada, M5T 1R8.
⁵ Laboratory Medicine and Pathobiology, University of Toronto, Medical Sciences Building, 1 King's College Cir, Toronto, ON, Canada M5S 1A8.
⁶ Alcohol Research and Treatment Clinic, Addiction Medicine Service, Acute Care Proram, , CAMH, Toronto, Ontario, Canada, M6J 1H4.
⁷ Campbell Family Mental Health Research Institute, CAMH, 33 Russell Street, Toronto, ON, Canada M5S 2S1.
⁸ Department of Family and Community Medicine, University of Toronto, 500 University Ave, Toronto, ON, Canada M5G 1V7.
⁹ Institute of Medical Sciences, University of Toronto, 27 King's College Cir, Toronto, ON, Canada ON M5S 1A8.

PMID: 35992511
PMCID: PMC9387363
DOI: 10.1097/cxa.0000000000000069

Association Study of OPRM1 Gene in a Sample of Schizophrenia Patients With Alcohol Dependence or Abuse

Marie N S Gendy et al. Can J Addict. 2019 Dec.

. 2019 Dec;10(4):30-34.

doi: 10.1097/cxa.0000000000000069.

Authors

Marie N S Gendy^{1

2}, Clement Zai^{3

4

5}, Bernard Le Foll^{1

6

7

8

2

3

9}, James L Kennedy^{3

4}

Affiliations

¹ Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, 33 Russell Street, Toronto, ON, Canada M5S 2S1.
² Department of Pharmacology, University of Toronto, Medical Science Building, 1 King's College Cir, Toronto, ON, Canada M5S 1A8.
³ Department of Psychiatry, Division of Brain and Therapeutics, University of Toronto, 250 College Street, Toronto, ON, Canada, M5T 1R8.
⁴ Neurogenetics Section, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Centre for Addiction and Mental Health, 250 College St. Toronto, ON, Canada, M5T 1R8.
⁵ Laboratory Medicine and Pathobiology, University of Toronto, Medical Sciences Building, 1 King's College Cir, Toronto, ON, Canada M5S 1A8.
⁶ Alcohol Research and Treatment Clinic, Addiction Medicine Service, Acute Care Proram, , CAMH, Toronto, Ontario, Canada, M6J 1H4.
⁷ Campbell Family Mental Health Research Institute, CAMH, 33 Russell Street, Toronto, ON, Canada M5S 2S1.
⁸ Department of Family and Community Medicine, University of Toronto, 500 University Ave, Toronto, ON, Canada M5G 1V7.
⁹ Institute of Medical Sciences, University of Toronto, 27 King's College Cir, Toronto, ON, Canada ON M5S 1A8.

PMID: 35992511
PMCID: PMC9387363
DOI: 10.1097/cxa.0000000000000069

Abstract

Alcohol use disorder is a complex disorder that is influenced by genetic factors. The non-synonymous single-nucleotide polymorphism (SNP) rs1799971 in exon 1 in opioid receptor OPRM1 was extensively studied in patients with alcohol dependence with mixed findings. Moreover, studies showed that opioid receptor polymorphism might play a role in the pathophysiology of schizophrenia. Our results suggest that rs1799971 SNP is not significantly associated with alcohol dependence in our sample of Schizophrenia patients of European ancestry.

Keywords: Mu opioid receptor gene (OPRM1); alcohol dependence; polymorphism; schizophrenia.

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Conflict of interest statement

Conflict of interest statement The authors declare no conflicts of interest.

Cited by

Ancestry: How researchers use it and what they mean by it.
Dauda B, Molina SJ, Allen DS, Fuentes A, Ghosh N, Mauro M, Neale BM, Panofsky A, Sohail M, Zhang SR, Lewis ACF. Dauda B, et al. Front Genet. 2023 Jan 23;14:1044555. doi: 10.3389/fgene.2023.1044555. eCollection 2023. Front Genet. 2023. PMID: 36755575 Free PMC article.

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Association Study of OPRM1 Gene in a Sample of Schizophrenia Patients With Alcohol Dependence or Abuse

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Association Study of OPRM1 Gene in a Sample of Schizophrenia Patients With Alcohol Dependence or Abuse

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