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. 2022 Aug 5:16:959523.
doi: 10.3389/fnhum.2022.959523. eCollection 2022.

Exploration of abnormal dynamic spontaneous brain activity in patients with high myopia via dynamic regional homogeneity analysis

Yu Ji  1 , Qi Cheng  1 , Wen-Wen Fu  1 , Pei-Pei Zhong  1 , Shui-Qin Huang  1 , Xiao-Lin Chen  1 , Xiao-Rong Wu  1
Affiliations

Exploration of abnormal dynamic spontaneous brain activity in patients with high myopia via dynamic regional homogeneity analysis

Yu Ji et al. Front Hum Neurosci. .

Abstract

Aim: Patients with high myopia (HM) reportedly exhibit changes in functional brain activity, but the mechanism underlying such changes is unclear. This study was conducted to observe differences in dynamic spontaneous brain activity between patients with HM and healthy controls (HCs) via dynamic regional homogeneity (dReHo) analysis.

Methods: Resting-state functional magnetic resonance imaging (rs-fMRI) scans were performed on 82 patients with HM and 59 HCs who were closely matched for age, sex, and weight. The dReHo approach was used to assess local dynamic activity in the human brain. The association between mean dReHo signal values and clinical symptoms in distinct brain areas in patients with HM was determined via correlation analysis.

Results: In the left fusiform gyrus (L-FG), right inferior temporal gyrus (R-ITG), right Rolandic operculum (R-ROL), right postcentral gyrus (R-PoCG), and right precentral gyrus (R-PreCG), dReHo values were significantly greater in patients with HM than in HCs.

Conclusion: Patients with HM have distinct functional changes in various brain regions that mainly include the L-FG, R-ITG, R-ROL, R-PoCG, and R-PreCG. These findings constitute important evidence for the roles of brain networks in the pathophysiological mechanisms of HM and may aid in the diagnosis of HM.

Keywords: brain function; brain region; dynamics regional homogeneity; high myopia; resting-state functional magnetic resonance imaging.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Distribution patterns of dReHo values are observed at the group level in HCs and patients with HM. Note: One-sample t-tests were used to compare dReHo maps between HCs (A) and patients with HM (B) (p < 0.01). HCs, healthy controls; HM, high myopia; dReHo, dynamic regional homogeneity analysis; L, left; R, right.
FIGURE 2
FIGURE 2
Comparison of differences in dReHo values between HCs and patients with HM. Significant differences in dReHo values are observed in the L-FG, R-ITG, R-ROL, R-PoCG, and R-PreCG. L-FG, left fusiform gyrus; R-ITG, right inferior temporal gyrus; R-ROL, right Rolandic operculum; R-PoCG, right postcentral gyrus; R-PreCG, right precentral gyrus.
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