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Comment
. 2023 Sep;19(3):293-302.
doi: 10.1007/s12024-022-00515-z. Epub 2022 Aug 22.

Evaluation of facial hair-associated SNPs: a pilot study on male Pakistani Punjabi population

Muhammad Jawad #  1 , Atif Adnan #  2   3 , Rahat Abdul Rehman  1 , Shahid Nazir  1 , Oyenike A Adeyemo  4 , S A M Amer  5 , Sibte Hadi  5 , Fan Liu  5   6 , Chuan-Chao Wang  7 , Allah Rakha  8
Affiliations
Comment

Evaluation of facial hair-associated SNPs: a pilot study on male Pakistani Punjabi population

Muhammad Jawad et al. Forensic Sci Med Pathol. 2023 Sep.

Abstract

Variation in facial hair is one of the most conspicuous features of facial appearance, particularly in South Asia and Middle East countries. A genome-wide association study in Latin Americans has identified multiple genetic variants at distinct loci being associated with facial hair traits including eyebrow thickness, beard thickness, and monobrow. In this pilot study, we have evaluated 16 SNPs associated with facial hair traits in 58 male individuals from the Punjabi population of Pakistan. In our sample, rs365060 in EDAR and rs12597422 in FTO showed significant association with monobrow, rs6684877 in MACF1 showed significant association with eyebrow thickness, and two SNPs in LOC105379031 (rs9654415 and rs7702331) showed significant association with beard thickness. Our results also suggest that genetic association may vary between ethnic groups and geographic regions. Although more data are needed to validate our results, our findings are of value in forensic molecular photofitting research in Pakistan.

Keywords: Forensics; Genotyping; Molecular photofitting; Punjab Pakistan; SNP association; SNaPshot.

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  • A genome-wide association scan in admixed Latin Americans identifies loci influencing facial and scalp hair features.
    Adhikari K, Fontanil T, Cal S, Mendoza-Revilla J, Fuentes-Guajardo M, Chacón-Duque JC, Al-Saadi F, Johansson JA, Quinto-Sanchez M, Acuña-Alonzo V, Jaramillo C, Arias W, Barquera Lozano R, Macín Pérez G, Gómez-Valdés J, Villamil-Ramírez H, Hunemeier T, Ramallo V, Silva de Cerqueira CC, Hurtado M, Villegas V, Granja V, Gallo C, Poletti G, Schuler-Faccini L, Salzano FM, Bortolini MC, Canizales-Quinteros S, Rothhammer F, Bedoya G, Gonzalez-José R, Headon D, López-Otín C, Tobin DJ, Balding D, Ruiz-Linares A. Adhikari K, et al. Nat Commun. 2016 Mar 1;7:10815. doi: 10.1038/ncomms10815. Nat Commun. 2016. PMID: 26926045 Free PMC article.

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