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Review
. 2023 Jul;23(3):667-678.
doi: 10.1007/s10238-022-00871-8. Epub 2022 Aug 22.

Coenzyme Q10 + alpha lipoic acid for chronic COVID syndrome

Maria Angela Barletta  1 , Gerardo Marino  1 , Barbara Spagnolo  2 , Francesco Paolo Bianchi  3 , Paola Chiara Francesca Falappone  1 , Luca Spagnolo  2 , Pietro Gatti  4
Affiliations
Review

Coenzyme Q10 + alpha lipoic acid for chronic COVID syndrome

Maria Angela Barletta et al. Clin Exp Med. 2023 Jul.

Abstract

Chronic COVID syndrome is characterized by chronic fatigue, myalgia, depression and sleep disturbances, similar to chronic fatigue syndrome (CFS) and fibromyalgia syndrome. Implementations of mitochondrial nutrients (MNs) with diet are important for the clinical effects antioxidant. We examined if use of an association of coenzyme Q10 and alpha lipoic acid (Requpero®) could reduce chronic covid symptoms. The Requpero study is a prospective observational study in which 174 patients, who had developed chronic-covid syndrome, were divided in two groups: The first one (116 patients) received coenzyme Q10 + alpha lipoic acid, and the second one (58 patients) did not receive any treatment. Primary outcome was reduction in Fatigue Severity Scale (FSS) in treatment group compared with control group. complete FSS response was reached most frequently in treatment group than in control group. A FSS complete response was reached in 62 (53.5%) patients in treatment group and in two (3.5%) patients in control group. A reduction in FSS core < 20% from baseline at T1 (non-response) was observed in 11 patients in the treatment group (9.5%) and in 15 patients in the control group (25.9%) (p < 0.0001). To date, this is the first study that tests the efficacy of coenzyme Q10 and alpha lipoic acid in chronic Covid syndrome. Primary and secondary outcomes were met. These results have to be confirmed through a double blind placebo controlled trial of longer duration.

Keywords: Chronic covid syndrome COVID-19; Coenzyme Q10; Fatigue severity scale; α-lipoic acid.

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Conflict of interest statement

The authors have no conflict of interest to declare that are relevant to the content of this article.

Figures

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The 2015 National Academy of medicine diagnostic criteria for ME/CFS
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FSS
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WPI
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SSS
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VAS pain
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VAS fatigue
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VAS sleep
See this image and copyright information in PMC

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