Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Dec;55(6 Pt 1):1044-1051.
doi: 10.1016/j.jmii.2022.07.009. Epub 2022 Aug 11.

Out-of-hospital cardiac arrest and in-hospital mortality among COVID-19 patients: A population-based retrospective cohort study

Shang-Yih Chan  1 , Yi-Fan Tsai  2 , Muh-Yong Yen  3 , Wen-Ruey Yu  4 , Chia-Chun Hung  5 , Tzu-Ling Kuo  5 , Chu-Chieh Chen  6 , Yung-Feng Yen  7 , Shih-Horng Huang  8 , Tsun-Cheng Huang  9 , Sheng-Jean Huang  10
Affiliations

Out-of-hospital cardiac arrest and in-hospital mortality among COVID-19 patients: A population-based retrospective cohort study

Shang-Yih Chan et al. J Microbiol Immunol Infect. 2022 Dec.

Abstract

Background/purpose: Predictors for out-of-hospital cardiac arrest (OHCA) in COVID-19 patients remain unclear. We identified the predictors for OHCA and in-hospital mortality among such patients in community isolation centers.

Methods: From May 15 to June 20, 2021, this cohort study recruited 2555 laboratory-confirmed COVID-19 patients admitted to isolation centers in Taiwan. All patients were followed up until death, discharge from the isolation center or hospital, or July 16, 2021. OHCA was defined as cardiac arrest confirmed by the absence of circulation signs and occurring outside the hospital. Multinomial logistic regressions were used to determine factors associated with OHCA and in-hospital mortality.

Results: Of the 37 deceased patients, 7 (18.9%) had OHCA and 30 (81.1%) showed in-hospital mortality. The mean (SD) time to OHCA was 6.6 (3.3) days from the symptom onset. After adjusting for demographics and comorbidities, independent predictors for OHCA included age ≥65 years (adjusted odds ratio [AOR]: 13.24, 95% confidence interval [CI]: 1.85-94.82), fever on admission to the isolation center (AOR: 12.53, 95% CI: 1.68-93.34), and hypoxemia (an oxygen saturation level below 95% on room air) (AOR: 26.54, 95% CI: 3.18-221.73). Predictors for in-hospital mortality included age ≥65 years (AOR: 10.28, 95% CI: 2.95-35.90), fever on admission to the isolation centers (AOR: 7.27, 95% CI: 1.90-27.83), and hypoxemia (AOR: 29.87, 95% CI: 10.17-87.76).

Conclusions: Time to OHCA occurrence is rapid in COVID-19 patients. Close monitoring of patients' vital signs and disease severity during isolation is important, particularly for those with older age, fever, and hypoxemia.

Keywords: COVID-19; Hypoxemia; Mortality; Out-of-hospital cardiac arrest; SARS-CoV-2.

PubMed Disclaimer

Conflict of interest statement

Declaration of competing interest No conflict of interest exists for the author.

Figures

Fig. 1
Figure 1
Progression of clinical symptoms in COVID-19 patients with out-of-hospital cardiac arrest. Abbreviations: COVID-19, coronavirus disease 2019.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. World health organization: coronavirus disease (COVID-19) pandemic. https://www.who.int/emergencies/diseases/novel-coronavirus-2019/
    1. Taiwan Centers for Disease Control and Prevention [Surveillance of COVID-19] https://www.cdc.gov.tw/En
    1. Tsai S.C., Chang W.W., Lee W.S. Analysis of an outbreak of COVID-19(alpha-variant) with rapid progression to mortality in Taipei, Taiwan. J Infect. 2022;84:e33–e34. - PMC - PubMed
    1. COVID-19 vaccination in taiwan. https://covid-19.nchc.org.tw/dt_002-csse_covid_19_daily_reports_vaccine_...
    1. Taiwan Centers for Disease Control and Prevention [Clinical management of COVID-19 patients] https://www.cdc.gov.tw/Category/Page/xCSwc5oznwcqunujPc-qmQ