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Comment
. 2022 Aug 22;7(1):294.
doi: 10.1038/s41392-022-01146-0.

Limited cross-variant neutralization after primary Omicron infection: consideration for a variant-containing booster

Harold Marcotte  1 , Lennart Hammarström  1 , Qiang Pan-Hammarström  2
Affiliations
Comment

Limited cross-variant neutralization after primary Omicron infection: consideration for a variant-containing booster

Harold Marcotte et al. Signal Transduct Target Ther. .
No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Cross-variant neutralization of SARS-CoV-2 isolates and consideration for boosting the immune response to SARS-CoV-2 variants. a Mice were infected with 1 × 104 p.f.u. of WA1, Delta, or Omicron. Unvaccinated or vaccinated individuals were infected with likely Delta or Omicron BA.1. The numbers in parentheses indicate the neutralization efficacy (NT50, 50% neutralization titer) of sera. The triple arrows indicate a higher neutralization activity against the indicated SARS-CoV-2 variants than the single arrow. The dash indicates no neutralization activity. The results suggest that the incorporation of Omicron-based immunogens in future multivalent/heterologous COVID-19 vaccination strategies may provide broader protection against VOCs. b Booster vaccination with WA.1 Spike has the potential to recruit previously-formed memory B cells, which undergo further affinity maturation through somatic hypermutations in their immunoglobulin genes. Omicron infection in those vaccinated individuals could reactivate those memory B cells that have sufficient affinity to recognize the variant despite many mutations in the RBD and spike. On the other hand, Omicron and WA.1 boost could, in theory, reactivate those memory B cells against more conserved epitopes as well as activate naive B cells specific for the Omicron spike. As the memory B cells have a pre-activated phenotype, they could respond more rapidly and outcompete naïve B cells, therefore the need to demonstrate new specificities derived from the naïve B cell response for a long period following the boost. The red cross indicates a B cell that do not recognize the Omicron variant but can be stimulated by the WA1 strain. MBCs Memory B cells, TfH T follicular Helper cells. The figure was generated using BioRender (https://biorender.com/)
See this image and copyright information in PMC

Comment on

  • Limited cross-variant immunity from SARS-CoV-2 Omicron without vaccination.
    Suryawanshi RK, Chen IP, Ma T, Syed AM, Brazer N, Saldhi P, Simoneau CR, Ciling A, Khalid MM, Sreekumar B, Chen PY, Kumar GR, Montano M, Gascon R, Tsou CL, Garcia-Knight MA, Sotomayor-Gonzalez A, Servellita V, Gliwa A, Nguyen J, Silva I, Milbes B, Kojima N, Hess V, Shacreaw M, Lopez L, Brobeck M, Turner F, Soveg FW, George AF, Fang X, Maishan M, Matthay M, Morris MK, Wadford D, Hanson C, Greene WC, Andino R, Spraggon L, Roan NR, Chiu CY, Doudna JA, Ott M. Suryawanshi RK, et al. Nature. 2022 Jul;607(7918):351-355. doi: 10.1038/s41586-022-04865-0. Epub 2022 May 18. Nature. 2022. PMID: 35584773 Free PMC article.

References

    1. Suryawanshi, R. K. et al. Limited cross-variant immunity from SARS-CoV-2 Omicron without vaccination. Nature10.1038/s41586-022-04865-0 (2022) - PMC - PubMed
    1. Cao, Y. et al. BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection. Nature10.1038/s41586-022-04980-y (2022). - PMC - PubMed
    1. Tuekprakhon, A. et al. Antibody escape of SARS-CoV-2 Omicron BA.4 and BA.5 from vaccine and BA.1 serum. Cell10.1016/j.cell.2022.06.005 (2022). - PMC - PubMed
    1. Muecksch, F. et al. Increased memory B cell potency and breadth after a SARS-CoV-2 mRNA boost. Nature10.1038/s41586-022-04778-y (2022). - PMC - PubMed
    1. Zuo F, et al. Heterologous immunization with inactivated vaccine followed by mRNA-booster elicits strong immunity against SARS-CoV-2 Omicron variant. Nat. Commun. 2022;13:2670. doi: 10.1038/s41467-022-30340-5. - DOI - PMC - PubMed

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