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Comment
. 2022 Aug 22;7(1):293.
doi: 10.1038/s41392-022-01144-2.

Caspase-7 and acid sphingomyelinase: partner repairmans of gasdermin and perforin pores

Ke Jin  1   2 , Guofang Shen  3
Affiliations
Comment

Caspase-7 and acid sphingomyelinase: partner repairmans of gasdermin and perforin pores

Ke Jin et al. Signal Transduct Target Ther. .
No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Caspase-7 antagonizes gasdermin D and perforin pores in inflammatory and apoptotic models and maintains cell membrane integrity by cleaving and activating acid sphingomyelinase (ASM) to produce sufficient ceramide for plasma membrane repair. Caspase-7 can be activated by pyroptotic caspase-1 in intestinal epithelial cells (IECs) (left), or acts downstream of granzyme B in infected hepatocytes which suffer from perforin-pore-mediated attack by natural killer (NK) cells or cytotoxic T lymphocytes (CTLs) (right). Then caspase-7 cleaves ASM, which generates more ceramide for endocytic repair of gasdermin D and perforin pores to facilitate IEC extrusion or target cell (infected hepatocytes in this model) apoptosis. C. Violaceum, Chromobacterium Violaceum; L. Monocytogenes, Listeria Monocytogenes
See this image and copyright information in PMC

Comment on

  • Caspase-7 activates ASM to repair gasdermin and perforin pores.
    Nozaki K, Maltez VI, Rayamajhi M, Tubbs AL, Mitchell JE, Lacey CA, Harvest CK, Li L, Nash WT, Larson HN, McGlaughon BD, Moorman NJ, Brown MG, Whitmire JK, Miao EA. Nozaki K, et al. Nature. 2022 Jun;606(7916):960-967. doi: 10.1038/s41586-022-04825-8. Epub 2022 Jun 15. Nature. 2022. PMID: 35705808 Free PMC article.

References

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