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. 2022 Aug 13:2022:2946891.
doi: 10.1155/2022/2946891. eCollection 2022.

sCD40L Is Increased and Associated with the Risk of Gestational Diabetes Mellitus in Pregnant Women with Isolated TPOAb Positivity

Xinxin Chen  1 , Qingyao Wang  1 , Xiangguo Cong  1 , Shuyi Jiang  2 , Shuxiang Li  2 , Qiong Shen  1 , Lei Chen  1
Affiliations

sCD40L Is Increased and Associated with the Risk of Gestational Diabetes Mellitus in Pregnant Women with Isolated TPOAb Positivity

Xinxin Chen et al. Int J Endocrinol. .

Abstract

Background: Autoimmune disorders are associated with gestational diabetes mellitus (GDM) in pregnant women who were positive for thyroid peroxidase antibody (TPOAb). Soluble CD40 ligand (sCD40L) and soluble interleukin-2 receptor (sCD25) are abnormally expressed in autoimmune diseases and are reliable markers of inflammation. The purpose of this study was to evaluate sCD40L and sCD25 in early pregnancy and investigate their correlation with GDM and TPOAb.

Methods: A total of 126 pregnant women in the first trimester were enrolled for analysis: 93 were positive for TPOAb and 33 were negative for TPOAb. Demographical and clinical data in early pregnancy were collected. A total of 123 participants underwent a 75 g oral glucose tolerance test in the second trimester. Serum sCD40L and sCD25 levels were measured by ELISA.

Results: The incidence of GDM was 24.4% in pregnant women with isolated TPOAb positivity in our study. Both sCD40L and sCD25 were positively correlated with TPOAb (r = 0.476, P < 0.001; r = 0.188, P < 0.05). sCD40L was highest in (P < 0.001) Ab-positive women with GDM group (P < 0.05). After adjusting for TPOAb, age, TSH, FT4, triglycerides, and low-density lipoprotein cholesterol, multivariate logistic regression analysis showed that sCD40L was an independent risk factor for GDM in pregnant women with TPOAb positivity (odds ratio = 3.235, 95% confidence interval 1.024-10.218, P < 0.05).

Conclusions: About a quarter of pregnant women with isolated positive TPOAb might have GDM. sCD40L was an independent risk factor for GDM in women with isolated TPOAb positivity.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Flow diagram of the study process.
Figure 2
Figure 2
The comparison of sCD40L and sCD25 according to TPOAb positivity and TPOAb titers (a) showed the comparison of sCD40L in the negative TPOAb group and the positive TPOAb group; (b) showed the comparison of sCD25 in the negative TPOAb group and the positive TPOAb group; (c) showed the comparison of sCD40L according to TPOAb titers; (d) showed the comparison of sCD25 according to TPOAb titers. Comparisons of sCD40L and sCD25 levels between the three groups were performed by ANOVA test and Bonferroni correction was used for post hoc tests.
Figure 3
Figure 3
Correlation analysis between sCD40L, sCD25, and TPOAb titers.
Figure 4
Figure 4
The comparison of sCD40L according to TPOAb positivity and the clinical fate of GDM. Comparison of sCD40L levels between the four groups was performed by ANOVA test and Bonferroni correction was used for post hoc tests.
See this image and copyright information in PMC

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