Single-molecule real-time sequencing of the M protein: Toward personalized medicine in monoclonal gammopathies

Pasquale Cascino^{1

2}, Alice Nevone^{1

2}, Maggie Piscitelli^{1

2}, Claudia Scopelliti^{1

2}, Maria Girelli^{1

2}, Giulia Mazzini^{1

2}, Serena Caminito^{1

2}, Giancarlo Russo³, Paolo Milani², Marco Basset^{1

2}, Andrea Foli^{1

2}, Francesca Fazio⁴, Simona Casarini^{1

2}, Margherita Massa², Margherita Bozzola^{1

2}, Jessica Ripepi^{1

2}, Melania Antonietta Sesta^{1

2}, Gloria Acquafredda^{5

6}, Marica De Cicco^{5

6}, Antonia Moretta^{5

6}, Paola Rognoni^{1

2}, Enrico Milan⁷, Stefano Ricagno^{8

9}, Francesca Lavatelli^{1

2}, Maria Teresa Petrucci⁴, Enkelejda Miho^{10

11

12}, Catherine Klersy¹³, Giampaolo Merlini^{1

2}, Giovanni Palladini^{1

2}, Mario Nuvolone^{1

2}

Affiliations

¹ Department of Molecular Medicine, University of Pavia, Pavia, Italy.
² Amyloidosis Research and Treatment Center, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
³ EMBL partner institute for genome editing, Life Science Center, Vilnius University, Vilnius, Lithuania.
⁴ Hematology, Department of Translational and Precision Medicine, Azienda Ospedaliera Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.
⁵ Pediatric Hematology Oncology Unit, Department of Maternal and Children's Health, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
⁶ Cell Factory and Center for Advanced Cellular Therapies, Department of Maternal and Children's Health, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
⁷ Age related Diseases Unit, Division of Genetics and Cell Biology, San Raffaele Scientific Institute and University Vita-Salute San Raffaele, Milan, Italy.
⁸ Department of Biosciences, Università degli Studi di Milano, Milan, Italy.
⁹ Institute of Molecular and Translational Cardiology, IRCCS Policlinico San Donato, Milan, Italy.
¹⁰ Institute of Medical Engineering and Medical Informatics, School of Life Sciences, University of Applied Sciences and Arts Northwestern Switzerland FHNW, Muttenz, Switzerland.
¹¹ SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland.
¹² aiNET GmbH, Basel, Switzerland.
¹³ Clinical Epidemiology and Biometry Service, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.

Free article

Pasquale Cascino et al. Am J Hematol. 2022 Nov.

Free article

. 2022 Nov;97(11):E389-E392.

doi: 10.1002/ajh.26684. Epub 2022 Aug 23.

¹ Department of Molecular Medicine, University of Pavia, Pavia, Italy.
² Amyloidosis Research and Treatment Center, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
³ EMBL partner institute for genome editing, Life Science Center, Vilnius University, Vilnius, Lithuania.
⁴ Hematology, Department of Translational and Precision Medicine, Azienda Ospedaliera Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.
⁵ Pediatric Hematology Oncology Unit, Department of Maternal and Children's Health, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
⁶ Cell Factory and Center for Advanced Cellular Therapies, Department of Maternal and Children's Health, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
⁷ Age related Diseases Unit, Division of Genetics and Cell Biology, San Raffaele Scientific Institute and University Vita-Salute San Raffaele, Milan, Italy.
⁸ Department of Biosciences, Università degli Studi di Milano, Milan, Italy.
⁹ Institute of Molecular and Translational Cardiology, IRCCS Policlinico San Donato, Milan, Italy.
¹⁰ Institute of Medical Engineering and Medical Informatics, School of Life Sciences, University of Applied Sciences and Arts Northwestern Switzerland FHNW, Muttenz, Switzerland.
¹¹ SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland.
¹² aiNET GmbH, Basel, Switzerland.
¹³ Clinical Epidemiology and Biometry Service, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.

No abstract available

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