Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Oct:172:53-64.
doi: 10.1016/j.lungcan.2022.08.004. Epub 2022 Aug 10.

The evolving role of liquid biopsy in lung cancer

Umberto Malapelle  1 , Pasquale Pisapia  2 , Francesco Pepe  2 , Gianluca Russo  2 , Mauro Buono  2 , Alessandro Russo  3 , Jorge Gomez  4 , Ola Khorshid  5 , Philip C Mack  4 , Christian Rolfo  4 , Giancarlo Troncone  2
Affiliations
Review

The evolving role of liquid biopsy in lung cancer

Umberto Malapelle et al. Lung Cancer. 2022 Oct.

Abstract

Liquid biopsy has revolutionized the management of cancer patients. In particular, liquid biopsy-based testing has proven to be highly beneficial for identifying actionable cancer markers, especially when solid tissue biopsies are insufficient or unattainable. Beyond the predictive role, liquid biopsy may be a useful tool for comprehensive tumor genotyping, identification of emergent resistance mechanisms, monitoring of minimal residual disease, early detection, and cancer interception. The application of next generation sequencing to liquid biopsy has led to the "quantum leap" of predictive molecular pathology. Here, we review the evolving role of liquid biopsy in lung cancer.

Keywords: Biomarkers; Liquid biopsy; NSCLC; ctDNA.

PubMed Disclaimer

Conflict of interest statement

Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Umberto Malapelle has received personal fees (as consultant and/or speaker bureau) from Boehringer Ingelheim, Roche, MSD, Amgen, Thermo Fisher Scientifics, Eli Lilly, Diaceutics, GSK, Merck and AstraZeneca, Janssen, Diatech, Novartis and Hedera unrelated to the current work. Pasquale Pisapia has received personal fees as speaker bureau from Novartis, for work performed outside of the current study. Alessandro Russo reports advisory board role/consultancy for AstraZeneca, Novartis, Pfizer and MSD, unrelated to the current work. Christian Rolfo reports grants from Pfizer and MSD, consulting fees from Archer, Inivata, BMS, Novartis, Boston Pharmaceuticals, MD Serono; other from AstraZeneca, Roche, GuardantHealth, and MSD; safety monitoring board for MD Serono; leadership roles with ISLB, IASLC, ESO and ESMO; other support from GuardantHealth, unrelated to the current work. Giancarlo Troncone reports personal fees (as speaker bureau or advisor) from Roche, MSD, Pfizer, Boehringer Ingelheim, Eli Lilly, BMS, GSK, Menarini, AstraZeneca, Amgen and Bayer, unrelated to the current work. The other Authors have nothing to disclose.

LinkOut - more resources