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Comment
. 2022 Aug 22;57(16):1917-1919.
doi: 10.1016/j.devcel.2022.07.013.

Rewiring bugs: Diet, the gut microbiome, and nerve regeneration

Sarah-Jane Leigh  1 , Gerard Clarke  2 , John F Cryan  3
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Free article
Comment

Rewiring bugs: Diet, the gut microbiome, and nerve regeneration

Sarah-Jane Leigh et al. Dev Cell. .
Free article

Abstract

Microbiome-to-nervous-system interactions are gaining much attention in fields that study health and disease, and diet is considered to be a key mediator in this communication. In a recent issue of Nature, Serger et al. show that, following nerve crush injury, intermittent fasting improves axonal regeneration through increased production of the microbially derived metabolite indole-3-propionate.

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Conflict of interest statement

Declaration of interests J.F.C. has been an invited speaker at conferences organized by Mead Johnson, Ordesa, and Yakult, and he has received research funding from Reckitt, Nutricia, Dupont/IFF, and Nestle. G.C. has received honoraria from Janssen, Probi, and Apsen as an invited speaker; is in receipt of research funding from Pharmavite and Fonterra; and is a paid consultant for Yakult and Zentiva. This support neither influenced nor constrained the contents of this preview. S.-J.L. declares no competing interests.

Comment on

  • The gut metabolite indole-3 propionate promotes nerve regeneration and repair.
    Serger E, Luengo-Gutierrez L, Chadwick JS, Kong G, Zhou L, Crawford G, Danzi MC, Myridakis A, Brandis A, Bello AT, Müller F, Sanchez-Vassopoulos A, De Virgiliis F, Liddell P, Dumas ME, Strid J, Mani S, Dodd D, Di Giovanni S. Serger E, et al. Nature. 2022 Jul;607(7919):585-592. doi: 10.1038/s41586-022-04884-x. Epub 2022 Jun 22. Nature. 2022. PMID: 35732737

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