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Comment
. 2023 Jul;72(7):1430-1431.
doi: 10.1136/gutjnl-2022-328262. Epub 2022 Aug 23.

Single-cell gene expression links SARS-CoV-2 infection and gut serotonin

Alyce M Martin  1 , Michael Roach  2 , Lauren A Jones  1 , Daniel Thorpe  1 , Rosemary A Coleman  1 , Caitlin Allman  1 , Robert Edwards  2 , Damien J Keating  3
Affiliations
Comment

Single-cell gene expression links SARS-CoV-2 infection and gut serotonin

Alyce M Martin et al. Gut. 2023 Jul.
No abstract available

Keywords: COVID-19; DIARRHOEA; GASTROINTESTINAL HORMONES; SEROTONIN.

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
Absolute expression of SARS-CoV-2-related genes in different cell types from the mouse small intestinal epithelium. Data are shown as colour scale of Log2 of mean copies per million (CPM), with circle size indicating fraction of each cell type expressing the gene.
Figure 2
Figure 2
Absolute expression levels of SARS-CoV-2 related genes in different enteroendocrine cell (EEC) types from the mouse small intestinal epithelium. Data are shown as colour scale of Log2 of mean copies per million (CPM), with circle size indicating fraction of each cell type expressing the gene.
See this image and copyright information in PMC

Comment on

  • Serotonin is elevated in COVID-19-associated diarrhoea.
    Ha S, Jin B, Clemmensen B, Park P, Mahboob S, Gladwill V, Lovely FM, Gottfried-Blackmore A, Habtezion A, Verma S, Ro S. Ha S, et al. Gut. 2021 Oct;70(10):2015-2017. doi: 10.1136/gutjnl-2020-323542. Epub 2021 Jan 5. Gut. 2021. PMID: 33402416 Free PMC article. No abstract available.

References

    1. Ha S, Jin B, Clemmensen B, et al. . Serotonin is elevated in COVID-19-associated diarrhoea. Gut 2021;70:2015–7. 10.1136/gutjnl-2020-323542 - DOI - PMC - PubMed
    1. Lin L, Jiang X, Zhang Z, et al. . Gastrointestinal symptoms of 95 cases with SARS-CoV-2 infection. Gut 2020;69:997–1001. 10.1136/gutjnl-2020-321013 - DOI - PubMed
    1. Yabut JM, Crane JD, Green AE, et al. . Emerging roles for serotonin in regulating metabolism: new implications for an ancient molecule. Endocr Rev 2019;40:1092–107. 10.1210/er.2018-00283 - DOI - PMC - PubMed
    1. Triana S, Metz-Zumaran C, Ramirez C, et al. . Single-cell analyses reveal SARS-CoV-2 interference with intrinsic immune response in the human gut. Mol Syst Biol 2021;17:e10232. 10.15252/msb.202110232 - DOI - PMC - PubMed
    1. Reis G, Dos Santos Moreira-Silva EA, Silva DCM, et al. . Effect of early treatment with fluvoxamine on risk of emergency care and hospitalisation among patients with COVID-19: the together randomised, platform clinical trial. Lancet Glob Health 2022;10:e42–51. 10.1016/S2214-109X(21)00448-4 - DOI - PMC - PubMed