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. 2022 Dec;48(12):1796-1798.
doi: 10.1007/s00134-022-06859-y. Epub 2022 Aug 23.

New drugs for acute kidney injury

Peter Pickkers  1 , Patrick T Murray  2 , Marlies Ostermann  3
Affiliations

New drugs for acute kidney injury

Peter Pickkers et al. Intensive Care Med. 2022 Dec.
No abstract available

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Conflict of interest statement

PP received speaker honoraria from Baxter and advisory board consulting reimbursement from AM-Pharma, EBI, Sphingotec, Adrenomed, 4Teen4. PM received Trial Steering Committee consultancy payments from AM-Pharma. Other consultancy payments: FAST Biomedical, Novartis, Renibus Therapeutics. MO received speaker honoraria from Fresenius Medical Care, Biomerieux, Baxter and Gilead, and research funding from Fresenius Medical Care, Biomerieux, Baxter and LaJolla Pharma and advisory board consultancy reimbursements from AM-Pharma.

Figures

Fig. 1
Fig. 1
Selected compounds that impact known pathophysiological processes and have been studied in humans. Alk Phos alkaline phosphatase; DAMP danger associated molecular pattern; IL interleukin; IFN-α interferon alpha; LPS lipopolysaccharide; NAD Nicotinamide adenine dinucleotide; T-regs regulatory T-cells; PAMP pathogen associated molecular pattern
See this image and copyright information in PMC

References

    1. Chawla LS, Eggers PW, Star RA, Kimmel PL. Acute kidney injury and chronic kidney disease as interconnected syndromes. N Engl J Med. 2014;371(1):58–66. doi: 10.1056/NEJMra1214243. - DOI - PMC - PubMed
    1. KDIGO KDIGO clinical practice guideline for acute kidney injury. Kidney International Supplements. KDIGO AKI Work Group. 2012;2:1–138.
    1. Pickkers P, Ostermann M, Joannidis M, Zarbock A, Hoste E, Bellomo R, et al. The intensive care medicine agenda on acute kidney injury. Intensive Care Med. 2017;43(9):1198–1209. doi: 10.1007/s00134-017-4687-2. - DOI - PMC - PubMed
    1. Ostermann M, Zarbock A, Goldstein S, Kashani K, Macedo E, Murugan R, et al. Recommendations on acute kidney injury biomarkers from the acute disease quality initiative consensus conference: a consensus statement. JAMA Netw Open. 2020;3(10):e2019209. doi: 10.1001/jamanetworkopen.2020.19209. - DOI - PubMed
    1. Pickkers P, Darmon M, Hoste E, Joannidis M, Legrand M, Ostermann M, et al. Acute kidney injury in the critically ill: an updated review on pathophysiology and management. Intensive Care Med. 2021;47(8):835–850. doi: 10.1007/s00134-021-06454-7. - DOI - PMC - PubMed

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