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. 2023 Jan;43(1):167-169.
doi: 10.1177/0271678X221121853. Epub 2022 Aug 23.

Preserving stroke penumbra by targeting lipid signalling

Beatriz Achón Buil  1   2 , Ruslan Rust  1   2
Affiliations

Preserving stroke penumbra by targeting lipid signalling

Beatriz Achón Buil et al. J Cereb Blood Flow Metab. 2023 Jan.

Abstract

Pharmacological inhibition of astrocytic enzyme autotaxin rescues the stroke penumbra in mice and improves functional recovery, indicating therapeutic potential.

Keywords: Autotaxin; hyperexcitability; ischemia; penumbra; therapy.

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Conflict of interest statement

The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Autotaxin (ATX) release by astrocytes is increased after ischemic stroke, resulting in higher levels of lysophosphatidic acid (LPA) which in turn rise the probability of glutamate release leading to hyperexcitability in the penumbra region. This signalling pathway is negatively regulated via LPA uptake by plasticity-related gene 1 (PRG-1).
See this image and copyright information in PMC

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