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. 2022 Jul 21;14(7):e27109.
doi: 10.7759/cureus.27109. eCollection 2022 Jul.

Current Trends in the Management of Epithelial Lacrimal Gland Tumors: A Retrospective National Cancer Database Analysis

Prashanth Ashok Kumar  1 , Dongliang Wang  2 , Danning Huang  2 , Shweta Paulraj  3 , Abirami Sivapiragasam  1
Affiliations

Current Trends in the Management of Epithelial Lacrimal Gland Tumors: A Retrospective National Cancer Database Analysis

Prashanth Ashok Kumar et al. Cureus. .

Abstract

Background: Lacrimal gland tumors are rare with data limited to very few large studies. Contemporary strategies like orbit sparing surgeries and neoadjuvant intraarterial chemotherapy remain controversial.

Methods: This is a retrospective cohort analysis of epithelial lacrimal gland tumors from the 2004-2016 National Cancer Database. Patients were stratified based on the type of surgery (limited vs destructive) and various treatment modalities employed.

Results: Squamous cell carcinoma (33.48%) and adenoid cystic carcinoma (29.45%) were the commonest histologies (N=669). Comparison of limited (46.33%) vs destructive procedures (53.11%) among 482 patients did not show any survival difference, nor the comparison between surgery vs ± chemotherapy vs ± radiotherapy among 472 patients.

Conclusion: Squamous cell carcinoma and adenoid cystic carcinoma are the commonest types of lacrimal gland tumors seen in our study. Tumor spread from adjacent sites may have contributed to the higher percentage of squamous cell carcinomas seen. The type of surgery or chemoradiation use did not alter survival.

Keywords: intra-arterial cytoreductive chemotherapy; lacrimal gland tumor; ncdb; orbit sparing surgery; orbital exenteration.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Summary and outline of methodology and patient population
NCDB: National Cancer Database; PUF: participant user file; SCC: squamous cell carcinoma; ACC: adenoid cystic carcinoma; CT: chemotherapy; RT: radiation therapy
Figure 2
Figure 2. Kaplan-Meier survival curves in months for limited and radical surgical procedures
Dx: diagnosis
Figure 3
Figure 3. Kaplan-Meier survival curves in months for the various combinitions of adjuvant and neoadjuvant chemotherapy and radiation therapy
RT: radiation therapy; Dx: diagnosis
See this image and copyright information in PMC

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