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. 2022 Jan-Dec:21:15330338221121086.
doi: 10.1177/15330338221121086.

Long-term Survival After Diverse Therapeutic Modalities in Malignant Phyllodes Tumors of the Breast

Hongyi Zhang  1 , Shasha Tang  1 , Ewelina Biskup  2 , Yi Zhang  1 , Liyun Yong  1 , Lijun Chen  3 , Fengfeng Cai  1
Affiliations

Long-term Survival After Diverse Therapeutic Modalities in Malignant Phyllodes Tumors of the Breast

Hongyi Zhang et al. Technol Cancer Res Treat. 2022 Jan-Dec.

Abstract

Background and Objects: Malignant phyllodes tumor of the breast (MPTB) is a rare tumor for which surgery or surgery combined with radiotherapy (RT) is the primary treatment method. However, recently, the therapeutic effect of RT on MPTB has been controversial. We aimed to explore the role of RT, chemotherapy (CT), and surgical modalities in patients with MPTB. Methods: The Surveillance, Epidemiology, and End Results (SEER) database was used to select patients with MPTB who met the criteria between 2010 and 2018. Kaplan-Meier curves and Cox proportional risk regression models were used to analyze the effects of RT on MPTB patients. Based on this, we compared the effects of breast-conserving surgery (BSC) and mastectomy on the postoperative survival of MPTB. Results: A total of 298 patients with MPTB were included in this study. RT was received by 22.1% (n = 66) of the patients while 77.9% (n = 232) did not receive RT. CT was received by 4.7% (n = 14) patients while 95.3% (n = 284) did not receive CT. According to Kaplan-Meier curves, RT and CT combined resulted in a decrease in breast cancer-specific survival (BCSS) and overall survival (OS) compared to patients who did not receive RT. Mastectomy improved the OS and BCSS of the patients more than BCS). The findings of univariate and multivariate Cox regression analyses suggested that "distant metastasis", "tumor grade" and "number of positive lymph node biopsies" affected OS of breast cancer, while "distant metastasis", "tumor grade", "surgery combined with radiotherapy/surgery", and "radiotherapy/chemotherapy or not", had a significant effect on BCSS. Conclusion: RT and CT did not significantly improve the long-term survival of MPTB patients. Mastectomy improved OS and BCSS of the patient more than BCS. RT in an early stage improved early prognosis moderately in MPTB patients with tumor diameter less than 50 mm.

Keywords: MPTB; SEER; breast; breast cancer; phyllodes tumor; survival.

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Conflict of interest statement

Declaration of Conflicting Interests: The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Kaplan–Meier survival curves for BCSS (left,Figure 1(a)) and OS (right,Figure 1(b)) of radiotherapy (RT) and non-RT groups. Kaplan–Meier survival curves for BCSS (left,Figure 1(c)) and OS (right,Figure 1(d)) of chemotherapy (CT) and non-CT groups.
Figure 2.
Figure 2.
Kaplan–Meier survival curves for BCSS (left,Figure 2(a)) and OS (right,Figure 2(b)) of BCS and mastectomy groups.
Figure 3.
Figure 3.
Kaplan–Meier survival curves for BCSS (left,Figure 3(a)) and OS (right,Figure 3(b)) for different tumor sizes and treatments.
See this image and copyright information in PMC

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