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. 2022 Oct;191(8):e2080.
doi: 10.1002/vetr.2080. Epub 2022 Aug 24.

Contrast-enhanced ultrasound features of focal pancreatic lesions in dogs

Silvia Burti  1 , Alessandro Zotti  1 , Giuseppe Rubini  2 , Riccardo Orlandi  3 , Paolo Bargellini  3 , Federico Bonsembiante  1 , Barbara Contiero  1 , Tommaso Banzato  1
Affiliations

Contrast-enhanced ultrasound features of focal pancreatic lesions in dogs

Silvia Burti et al. Vet Rec. 2022 Oct.

Abstract

Background: Contrast-enhanced ultrasound (CEUS) features of pancreatic lesions are poorly reported in veterinary literature.

Methods: Qualitative and quantitative features of pancreatic benign (nodular hyperplasia [NH], cyst and abscess) and malignant (adenocarcinoma and insulinoma) lesions during B-mode and CEUS examinations are described in 75 dogs.

Results: Adenocarcinomas (n = 23) had mixed echogenicity at B-mode, and they were hypoenhancing or non-enhancing at CEUS, with a non-homogeneous and cystic enhancement pattern. Insulinomas (n = 23) appeared as hypoechoic lesions at B-mode, and as hyperenhancing, homogeneous and solid lesions at CEUS. NH (n = 17) had an constant appearance, being hypoechoic at ultrasound (US) and isoenhancing at CEUS. Cysts (n = 7) were all anechoic, with acoustic enhancement clearly detectable at US, but were non-enhancing at CEUS. Lastly, abscesses (n = 5) had mixed echogenicity, and they showed both hyperenhancement and non-enhancement at CEUS. Hypoenhancement and non-homogeneous appearance had a moderate diagnostic accuracy in the detection of adenocarcinomas. In particular, hyperenhancement was evident only in malignant lesions (adenocarcinomas and insulinomas).

Conclusion: CEUS, in combination with B-mode US features, is a valuable tool for distinction of benign and malignant abnormalities of the pancreas and can potentially differentiate insulinomas from adenocarcinomas.

Keywords: carcinoma; contrast-enhanced ultrasound; cytology; dog; focal pancreatic lesion; insulinoma.

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