Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Dec;44(1):1409-1416.
doi: 10.1080/0886022X.2022.2114369.

Relationship between serum parathyroid hormone levels and abdominal aortic calcification in patients starting hemodialysis who have never taken calcium tablets, calcitriol, or vitamin D analogs

Jin He  1 , Xiaoyan Sun  1 , Rongjian Nie  1 , Lin Zhao  2
Affiliations

Relationship between serum parathyroid hormone levels and abdominal aortic calcification in patients starting hemodialysis who have never taken calcium tablets, calcitriol, or vitamin D analogs

Jin He et al. Ren Fail. 2022 Dec.

Abstract

Background: Vascular calcification (VC) and secondary hyperparathyroidism (SHPT) are important causes of the high incidence of cardiovascular events in chronic kidney disease (CKD) patients. The relationship between parathyroid hormone (PTH) and VC is very complex. The aim of this study was to determine the correlation between PTH levels and abdominal aortic calcification (AAC) in patients starting hemodialysis who had not received calcium tablets, calcium-containing phosphorus binders, calcitriol, or vitamin D analogs.

Methods: Seventy-one patients were included. Latero-lateral X-ray lumbar radiography, serum intact PTH (iPTH) levels, and predialysis biochemical parameters were obtained. The degree of AAC was evaluated according to the methods described previously by Kauppila et al.

Results: We found that there was a strong negative correlation between serum PTH and AAC (Spearman's rho -0.76, p < 0.001). Receiver operating characteristic (ROC) curve analysis showed that low serum PTH level could predict the presence and extent of AAC (area under the curve values were 0.9013 [p < 0.0001] and 0.780 [p = 0.0041], respectively).

Conclusions: Our results indicate that serum PTH level is significantly negatively correlated with AAC within a certain concentration range in patients starting hemodialysis who had not received calcium tablets, calcium-containing phosphorus binders, calcitriol, or vitamin D analogs.

Keywords: Chronic kidney disease; abdominal aortic calcification; parathyroid hormone; vascular calcification.

PubMed Disclaimer

Conflict of interest statement

No potential conflict of interest was reported by the author(s).

Figures

Figure 1.
Figure 1.
(A) Representative image of AAC in the low-serum-iPTH group of non-DKD patients. (B) Representative image of AAC in the high-serum-iPTH group of non-DKD patients. (C) Representative image of AAC in the low-serum-iPTH group of DKD patients. (D) Representative image of AAC in the high-serum-iPTH group of DKD patients.
Figure 2.
Figure 2.
Receiver operating characteristic curve analysis showing the prognostic value of PTH levels in predicting the presence of AAC. The 95% confidence intervals are provided. AUC: area under the curve.
Figure 3.
Figure 3.
Receiver operating characteristic curve analysis showing the prognostic value of PTH levels in predicting severe and extensive calcification (AAC score ≥ 6). The 95% confidence intervals are provided. AUC: area under the curve.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Foley RN, Parfrey PS, Sarnak MJ.. Clinical epidemiology of cardiovascular disease in chronic renal disease. Am J Kidney Dis. 1998;32(5):S112–S119. - PubMed
    1. Paloian NJ, Giachelli CM.. A current understanding of vascular calcification in CKD. Am J Physiol Renal Physiol. 2014;307(8):F891–F900. - PMC - PubMed
    1. Mizobuchi M, Towler D, Slatopolsky E.. Vascular calcification: the killer of patients with chronic kidney disease. J Am Soc Nephrol. 2009;20(7):1453–1464. - PubMed
    1. Russo D, Corrao S, Battaglia Y, et al. . Progression of coronary artery calcification and cardiac events in patients with chronic renal disease not receiving dialysis. Kidney Int. 2011;80(1):112–118. - PMC - PubMed
    1. London GM, Guérin AP, Marchais SJ, et al. . Arterial media calcification in end-stage renal disease: impact on all-cause and cardiovascular mortality. Nephrol Dial Transplant. 2003;18(9):1731–1740. - PubMed

LinkOut - more resources