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Case Reports
. 2022 Jul;39(4):601-605.
doi: 10.1111/pde.15074.

Toxic epidermal necrolysis after first dose of Pfizer-BioNTech (BNT162b2) vaccination with pharmacogenomic testing

Nunthana Siripipattanamongkol  1 , Sirawich Rattanasak  1 , Chanya Taiyaitieng  2 , Yanapha Inthajak  3 , Nitchamon Kuawatcharawong  4 , Chonlaphat Sukasem  5   6   7 , Therdpong Tempark  8
Affiliations
Case Reports

Toxic epidermal necrolysis after first dose of Pfizer-BioNTech (BNT162b2) vaccination with pharmacogenomic testing

Nunthana Siripipattanamongkol et al. Pediatr Dermatol. 2022 Jul.

Abstract

Toxic epidermal necrolysis (TEN) is a rare and acute life-threatening condition and one of the severe cutaneous adverse drug reactions. There are limited data on TEN from the COVID-19 vaccine regarding its pathogenesis, treatment, and prognosis, particularly in children. We report a case of COVID-19 vaccine-induced TEN and the patient's human leukocyte antigen pharmacogenomic profile.

Keywords: COVID-19 vaccine; pharmacogenomics; toxic epidermal necrolysis.

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Conflict of interest statement

None declared.

Figures

FIGURE 1
FIGURE 1
Second day of admission, rapid progressive necrosis and denuded area at face and oral mucosa with worsening ophthalmologic symptoms.
FIGURE 2
FIGURE 2
A wide‐spread area of necrotic skin at the back with Nikolsky sign.
FIGURE 3
FIGURE 3
Biopsy of full thickness epidermal necrosis with keratinocytes necrosis.
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References

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