Electrospun nanofibers with antibacterial properties for wound dressings

Abstract

The antibacterial nanofibers have been proposed as an interesting material for wound healing management, since the majority of traditional wound dressings exhibit issues and complications such as infection, pain, discomfort, and poor adhesive proprieties. It allows the organism's passage through the dressing and delay the wound healing progression. Electrospun nanofibers have been intensively investigated for wound dressings in tissue engineering applications due to their distinctive features and structural similarities to the extracellular matrix including the various available methods to load the antibacterial compounds onto the nanofiber webs. To construct an effective electrospun wound dressing, various efforts have been made to design different strategies to develop advanced polymers, such as employing synthetic and/or natural materials, modifying fiber orientation, and incorporating chemicals and metallic nanoparticles (NPs) as intriguing materials for antibacterial bandages. Thus, this review summarizes the relevant recent studies on the production of electrospun antibacterial nanofibers from a wide variety of polymers used in biomedical applications for wound dressings.

Keywords: Electrospun nanofibers; antibacterial; biomedical; wound dressings.