Response to Comment on "Microglial activation states drive glucose uptake and FDG-PET alterations in neurodegenerative diseases"

Xianyuan Xiang^{1

2}, Sabina Tahirovic³, Sibylle Ziegler^{4

5}, Christian Haass^{1

3

5}, Matthias Brendel^{3

4

5}

Affiliations

¹ Biomedical Center (BMC), Division of Metabolic Biochemistry, Faculty of Medicine, Ludwig-Maximilians-Universität München, 81377 Munich, Germany.
² CAS Key Laboratory of Brain Connectome and Manipulation, the Brain Cognition and Brain Disease Institute, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen 518055, China.
³ German Center for Neurodegenerative Diseases (DZNE) Munich, 81377 Munich, Germany.
⁴ Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, 81377 Munich, Germany.
⁵ Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany.

Comment

Xianyuan Xiang et al. Sci Transl Med. 2022.

. 2022 Aug 24;14(659):eabn5104.

doi: 10.1126/scitranslmed.abn5104. Epub 2022 Aug 24.

Xianyuan Xiang^{1

2}, Sabina Tahirovic³, Sibylle Ziegler^{4

5}, Christian Haass^{1

3

5}, Matthias Brendel^{3

4

5}

¹ Biomedical Center (BMC), Division of Metabolic Biochemistry, Faculty of Medicine, Ludwig-Maximilians-Universität München, 81377 Munich, Germany.
² CAS Key Laboratory of Brain Connectome and Manipulation, the Brain Cognition and Brain Disease Institute, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen 518055, China.
³ German Center for Neurodegenerative Diseases (DZNE) Munich, 81377 Munich, Germany.
⁴ Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, 81377 Munich, Germany.
⁵ Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany.

Abstract

Microglial FDG uptake alterations are the source of FDG-PET changes in models of neurodegenerative diseases.

Microglial activation states drive glucose uptake and FDG-PET alterations in neurodegenerative diseases.
Xiang X, Wind K, Wiedemann T, Blume T, Shi Y, Briel N, Beyer L, Biechele G, Eckenweber F, Zatcepin A, Lammich S, Ribicic S, Tahirovic S, Willem M, Deussing M, Palleis C, Rauchmann BS, Gildehaus FJ, Lindner S, Spitz C, Franzmeier N, Baumann K, Rominger A, Bartenstein P, Ziegler S, Drzezga A, Respondek G, Buerger K, Perneczky R, Levin J, Höglinger GU, Herms J, Haass C, Brendel M. Xiang X, et al. Sci Transl Med. 2021 Oct 13;13(615):eabe5640. doi: 10.1126/scitranslmed.abe5640. Epub 2021 Oct 13. Sci Transl Med. 2021. PMID: 34644146
Comment on "Microglial activation states drive glucose uptake and FDG-PET alterations in neurodegenerative diseases".
Zimmer ER, Pascoal TA, Rosa-Neto P, Nordberg A, Pellerin L. Zimmer ER, et al. Sci Transl Med. 2022 Aug 24;14(659):eabm8302. doi: 10.1126/scitranslmed.abm8302. Epub 2022 Aug 24. Sci Transl Med. 2022. PMID: 36001681