Comment on "Microglial activation states drive glucose uptake and FDG-PET alterations in neurodegenerative diseases"

Eduardo R Zimmer^{1

2

3

4

5}, Tharick A Pascoal^{5

6

7

8}, Pedro Rosa-Neto^{5

8

9

10}, Agneta Nordberg^{11

12}, Luc Pellerin¹³

Affiliations

¹ Department of Pharmacology, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul (RS) 90035-003, Brazil.
² Graduate Program in Biological Sciences: Biochemistry, UFRGS, Porto Alegre, RS 90035-003, Brazil.
³ Graduate Program in Biological Sciences: Pharmacology and Therapeutics, UFRGS, Porto Alegre, RS 90035-003, Brazil.
⁴ Brain Institute of Rio Grande Do Sul, Pontifical Catholic University of Rio Grande Do Sul, Porto Alegre, RS 90610-000, Brazil.
⁵ McGill Centre for Studies in Aging, McGill University, Montreal, Quebec H4H 1R3, Canada.
⁶ Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
⁷ Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
⁸ Translational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, McGill University, Montreal, Quebec H4H 1R3, Canada.
⁹ Departments of Neurology and Neurosurgery, McGill University, Montreal, Quebec H3A 1A1, Canada.
¹⁰ Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada.
¹¹ Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm 141 52, Sweden.
¹² Theme Aging, Karolinska University Hospital, Stockholm 141 52, Sweden.
¹³ IRMETIST, Inserm U1313, University of Poitiers and CHU of Poitiers, Poitiers 86021, France.

PMID: 36001681
DOI: 10.1126/scitranslmed.abm8302

Comment

Comment on "Microglial activation states drive glucose uptake and FDG-PET alterations in neurodegenerative diseases"

Eduardo R Zimmer et al. Sci Transl Med. 2022.

. 2022 Aug 24;14(659):eabm8302.

doi: 10.1126/scitranslmed.abm8302. Epub 2022 Aug 24.

Authors

Eduardo R Zimmer^{1

2

3

4

5}, Tharick A Pascoal^{5

6

7

8}, Pedro Rosa-Neto^{5

8

9

10}, Agneta Nordberg^{11

12}, Luc Pellerin¹³

Affiliations

¹ Department of Pharmacology, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul (RS) 90035-003, Brazil.
² Graduate Program in Biological Sciences: Biochemistry, UFRGS, Porto Alegre, RS 90035-003, Brazil.
³ Graduate Program in Biological Sciences: Pharmacology and Therapeutics, UFRGS, Porto Alegre, RS 90035-003, Brazil.
⁴ Brain Institute of Rio Grande Do Sul, Pontifical Catholic University of Rio Grande Do Sul, Porto Alegre, RS 90610-000, Brazil.
⁵ McGill Centre for Studies in Aging, McGill University, Montreal, Quebec H4H 1R3, Canada.
⁶ Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
⁷ Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
⁸ Translational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, McGill University, Montreal, Quebec H4H 1R3, Canada.
⁹ Departments of Neurology and Neurosurgery, McGill University, Montreal, Quebec H3A 1A1, Canada.
¹⁰ Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada.
¹¹ Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm 141 52, Sweden.
¹² Theme Aging, Karolinska University Hospital, Stockholm 141 52, Sweden.
¹³ IRMETIST, Inserm U1313, University of Poitiers and CHU of Poitiers, Poitiers 86021, France.

PMID: 36001681
DOI: 10.1126/scitranslmed.abm8302

Abstract

Astrocytes might be the major contributor to the radioactive signal captured by PET in the microglia-dependent modulation of FDG-PET.

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Comment in

Response to Comment on "Microglial activation states drive glucose uptake and FDG-PET alterations in neurodegenerative diseases".
Xiang X, Tahirovic S, Ziegler S, Haass C, Brendel M. Xiang X, et al. Sci Transl Med. 2022 Aug 24;14(659):eabn5104. doi: 10.1126/scitranslmed.abn5104. Epub 2022 Aug 24. Sci Transl Med. 2022. PMID: 36001676

Comment on

Microglial activation states drive glucose uptake and FDG-PET alterations in neurodegenerative diseases.
Xiang X, Wind K, Wiedemann T, Blume T, Shi Y, Briel N, Beyer L, Biechele G, Eckenweber F, Zatcepin A, Lammich S, Ribicic S, Tahirovic S, Willem M, Deussing M, Palleis C, Rauchmann BS, Gildehaus FJ, Lindner S, Spitz C, Franzmeier N, Baumann K, Rominger A, Bartenstein P, Ziegler S, Drzezga A, Respondek G, Buerger K, Perneczky R, Levin J, Höglinger GU, Herms J, Haass C, Brendel M. Xiang X, et al. Sci Transl Med. 2021 Oct 13;13(615):eabe5640. doi: 10.1126/scitranslmed.abe5640. Epub 2021 Oct 13. Sci Transl Med. 2021. PMID: 34644146

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Comment on "Microglial activation states drive glucose uptake and FDG-PET alterations in neurodegenerative diseases"

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Comment on "Microglial activation states drive glucose uptake and FDG-PET alterations in neurodegenerative diseases"

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