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Comment
. 2022 Nov;32(11):967-968.
doi: 10.1038/s41422-022-00715-w.

Fine-tuning T cell function through engineered orthogonal chimeric cytokine receptors

Rigel J Kishton  1 , Nicholas P Restifo  2
Affiliations
Comment

Fine-tuning T cell function through engineered orthogonal chimeric cytokine receptors

Rigel J Kishton et al. Cell Res. 2022 Nov.
No abstract available

PubMed Disclaimer

Conflict of interest statement

R.J.K. and N.P.R. receive compensation and own equity in Lyell Immunopharma.

Figures

Fig. 1
Fig. 1. Orthogonal IL-2 systems mediate specific expansion of therapeutic T cells.
a Expansion of mixed populations of therapeutic and suppressive/irrelevant T cells with endogenous IL-2 may lead to preferential expansion of clinically irrelevant T cells. b Engineering therapeutic T cells with an orthogonal IL-2R can allow for preferential expansion of these cells through administration of orthogonal IL-2. c Engineering therapeutic T cells with a chimeric orthogonal IL-2R expressing ICD of the IL-9R can allow for preferential expansion of these cells and engage alternative signaling cascades to promote desired cellular phenotypes.
See this image and copyright information in PMC

Comment on

  • Potentiating adoptive cell therapy using synthetic IL-9 receptors.
    Kalbasi A, Siurala M, Su LL, Tariveranmoshabad M, Picton LK, Ravikumar P, Li P, Lin JX, Escuin-Ordinas H, Da T, Kremer SV, Sun AL, Castelli S, Agarwal S, Scholler J, Song D, Rommel PC, Radaelli E, Young RM, Leonard WJ, Ribas A, June CH, Garcia KC. Kalbasi A, et al. Nature. 2022 Jul;607(7918):360-365. doi: 10.1038/s41586-022-04801-2. Epub 2022 Jun 8. Nature. 2022. PMID: 35676488 Free PMC article.

References

    1. Curtsinger JM, Mescher MF. Curr. Opin. Immunol. 2010;22:333–340. doi: 10.1016/j.coi.2010.02.013. - DOI - PMC - PubMed
    1. June CH, O’Connor RS, Kawalekar OU, Ghassemi S, Milone MC. Science. 2018;359:1361–1365. doi: 10.1126/science.aar6711. - DOI - PubMed
    1. Klebanoff CA, et al. Proc. Natl. Acad. Sci. USA. 2004;101:1969–1974. doi: 10.1073/pnas.0307298101. - DOI - PMC - PubMed
    1. Hinrichs CS, et al. Blood. 2008;111:5326–5333. doi: 10.1182/blood-2007-09-113050. - DOI - PMC - PubMed
    1. Rosenberg SA, Restifo NP. Science. 2015;348:62–68. doi: 10.1126/science.aaa4967. - DOI - PMC - PubMed

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