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Meta-Analysis
. 2022 Aug 24;22(1):503.
doi: 10.1186/s12887-022-03545-2.

The global survival rate of graft and patient in kidney transplantation of children: a systematic review and meta-analysis

Mousa Ghelichi-Ghojogh  1 , Fateme Mohammadizadeh  2 , Fatemeh Jafari  2 , Mouhebat Vali  2 , Sepideh Jahanian  3 , Masoud Mohammadi  4 , Alireza Jafari  5 , Rozhan Khezri  6 , Hossein-Ali Nikbakht  7 , Masumeh Daliri  2 , Abdolhalim Rajabi  8
Affiliations
Meta-Analysis

The global survival rate of graft and patient in kidney transplantation of children: a systematic review and meta-analysis

Mousa Ghelichi-Ghojogh et al. BMC Pediatr. .

Abstract

Background: This study is a systematic review and meta-analysis on published studies about the Global Survival Rate of Graft and Patients in the Kidney Transplantation of children.

Methods: Studies that investigated the survival rate of kidney transplants published until the 30th of December 2020 were selected using a systematic search strategy in the following databases: Medline, Embase, Scopus, ProQuest, ISI Web of Science, and Cochrane. The extracted data were entered into the Excel software and STATA 16.0. The search identified 6007 study references. From the total, we excluded 1348 duplicates, 3688 reference titles and abstracts that were deemed irrelevant, and 846 references that were not original articles (i.e., letter, commentary, review) or did not meet the inclusion criteria. As such, 89 studies involving 12,330 participants were included in this meta-analysis.

Results: In this study 1, 3, 5, 7 and 10-year survival rates of graft were estimated to be 92, 83, 74.40, 67.10, and 63.50%, respectively. Also, 1, 3, 5, 7 and 10-year survival rates of patients were estimated to be 99.60, 97.30, 95.20, 74.60, and 97.90%, respectively.

Conclusions: The findings suggest differences in graft and patient survival among children with kidney transplants. Although differences in ethnic origin, incompatibility with deceased donor kidneys, and types of kidney disease are unavoidable, interventions to improve preventive and living-donor transplantation are particularly needed in minority groups. In addition, more research is needed to establish and address the contribution of medical and sociocultural barriers to preferential treatment of these groups.

Keywords: Graft survival; Kidney transplantation; Meta-analysis; Patient survival.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Flowchart of the included eligible studies in systematic review
Fig. 2
Fig. 2
One-year survival rate of Graft kidney transplantation in children
Fig. 3
Fig. 3
Three-year survival rate of Graft kidney transplantation in children
Fig. 4
Fig. 4
Five-year survival rate of Graft kidney transplantation in children
Fig. 5
Fig. 5
Ten-year survival rate of Graft kidney transplantation in children
Fig. 6
Fig. 6
One-year survival rate of Patients kidney transplantation in children
Fig. 7
Fig. 7
Three-year survival rate of Patients kidney transplantation in children
Fig. 8
Fig. 8
Five-year survival rate of patients kidney transplantation in children
Fig. 9
Fig. 9
Ten-year survival rate of Patients kidney transplantation in children
See this image and copyright information in PMC

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