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Case Reports
. 2022 Aug 8:10:935118.
doi: 10.3389/fped.2022.935118. eCollection 2022.

Case report: Application of nirmatrelvir/ritonavir to treat COVID-19 in a severe aplastic anemia child after allogeneic hematopoietic stem cell transplantation

Jinhua Huang  1 , Di Yin  1 , Xia Qin  2 , Mei Yu  1 , Beilei Jiang  1 , Jing Chen  2 , Qing Cao  3 , Zhiguo Tang  1
Affiliations
Case Reports

Case report: Application of nirmatrelvir/ritonavir to treat COVID-19 in a severe aplastic anemia child after allogeneic hematopoietic stem cell transplantation

Jinhua Huang et al. Front Pediatr. .

Abstract

We present a case report of successful treatment with nirmatrelvir/ritonavir (Paxlvoid) for a severe aplastic anemia child with COVID-19, cytopenia, and mixed chimerism of donor hematopoietic cells at 3 months after allogeneic hematopoietic stem cell transplantation. After the 5-day entire course of treatment, the clinical symptoms were relieved, cycle threshold values of ORF1a/b and N genes increased from 22.60 and 22.15 to 34.52 and 33.84, respectively, and the peripheral blood counts gradually recovered without graft failure. Nirmatrelvir/ritonavir can effectively inhibit the replication of SARS-CoV-2 without any significant adverse effects.

Keywords: COVID-19; Omicron; Paxlovid; children; severe aplastic anemia; transplantation.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Trend of hematologic parameters over times.
FIGURE 2
FIGURE 2
Trend of Ct values of ORF1a/b and N genes over times.
See this image and copyright information in PMC

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